Biodegradable ring-shaped implantable device for intravesical therapy of bladder disorders

Hyunjoon Kim; Seung Ho Lee; Adam Wentworth; Sahab Babaee; Kaitlyn Wong; Joy E Collins; Jacqueline Chu; Keiko Ishida; Johannes Kuosmanen; Joshua Jenkins; Kaitlyn Hess; Aaron Lopes; Joshua Morimoto; Qianqian Wan; Shaunak V Potdar; Ronan McNally; Caitlynn Tov; Na Yoon Kim; Alison Hayward; Daniel Wollin; Robert Langer; Giovanni Traverso

doi:10.1016/j.biomaterials.2022.121703

Biodegradable ring-shaped implantable device for intravesical therapy of bladder disorders

Biomaterials. 2022 Sep:288:121703. doi: 10.1016/j.biomaterials.2022.121703. Epub 2022 Aug 17.

Authors

Hyunjoon Kim¹, Seung Ho Lee¹, Adam Wentworth², Sahab Babaee¹, Kaitlyn Wong³, Joy E Collins³, Jacqueline Chu⁴, Keiko Ishida², Johannes Kuosmanen¹, Joshua Jenkins¹, Kaitlyn Hess¹, Aaron Lopes², Joshua Morimoto¹, Qianqian Wan¹, Shaunak V Potdar³, Ronan McNally³, Caitlynn Tov³, Na Yoon Kim¹, Alison Hayward⁵, Daniel Wollin⁶, Robert Langer⁷, Giovanni Traverso⁸

Affiliations

¹ The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
² The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
³ Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
⁴ The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Division of Gastroenterology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, 02114, USA.
⁵ The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; Division of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
⁶ Division of Urology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
⁷ The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
⁸ The David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA; Division of Gastroenterology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA. Electronic address: ctraverso@bwh.harvard.edu.

Abstract

Intravesical instillation is an efficient drug delivery route for the local treatment of various urological conditions. Nevertheless, intravesical instillation is associated with several challenges, including pain, urological infection, and frequent clinic visits for catheterization; these difficulties support the need for a simple and easy intravesical drug delivery platform. Here, we propose a novel biodegradable intravesical device capable of long-term, local drug delivery without a retrieval procedure. The intravesical device is composed of drug encapsulating biodegradable polycaprolactone (PCL) microcapsules and connected by a bioabsorbable Polydioxanone (PDS) suture with NdFeB magnets in the end. The device is easily inserted into the bladder and forms a 'ring' shape optimized for maximal mechanical stability as informed by finite element analysis. In this study, inserted devices were retained in a swine model for 4 weeks. Using this device, we evaluated the system's capacity for delivery of lidocaine and resiquimod and demonstrated prolonged drug release. Moreover, a cost-effectiveness analysis supports device implementation compared to the standard of care. Our data support that this device can be a versatile drug delivery platform for urologic medications.

Keywords: Biodegradable; Bladder disorders; Drug delivery; Implantable device.

Publication types

Research Support, Non-U.S. Gov't
Research Support, N.I.H., Extramural

MeSH terms

Administration, Intravesical
Animals
Drug Delivery Systems* / methods
Drug Liberation
Swine
Urinary Bladder* / metabolism

Grants and funding

T32 DK007191/DK/NIDDK NIH HHS/United States