Deciphering clock genes as emerging targets against aging

Yanli Zhu; Yanqing Liu; Germaine Escames; Zhi Yang; Huadong Zhao; Lu Qian; Chengxu Xue; Danni Xu; Darío Acuña-Castroviejo; Yang Yang

doi:10.1016/j.arr.2022.101725

Deciphering clock genes as emerging targets against aging

Ageing Res Rev. 2022 Nov:81:101725. doi: 10.1016/j.arr.2022.101725. Epub 2022 Aug 25.

Authors

Affiliations

¹ Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China.
² Biomedical Research Center, Health Sciences Technology Park, University of Granada, Avda. del Conocimiento s/n, Granada, Spain; Ibs. Granada and CIBERfes, Granada, Spain; UGC of Clinical Laboratories, Universitu San Cecilio's Hospital, Granada, Spain.
³ Department of General Surgery, Tangdu Hospital, The Airforce Medical University, 1 Xinsi Road, Xi'an, China.
⁴ Biomedical Research Center, Health Sciences Technology Park, University of Granada, Avda. del Conocimiento s/n, Granada, Spain; Ibs. Granada and CIBERfes, Granada, Spain; UGC of Clinical Laboratories, Universitu San Cecilio's Hospital, Granada, Spain. Electronic address: dacuna@ugr.es.
⁵ Xi'an Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Xi'an No.3 Hospital, The Affiliated Hospital of Northwest University, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China; Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education, Faculty of Life Sciences and Medicine, Northwest University, Xi'an, China. Electronic address: yang200214yy@163.com.

PMID: 36029999
DOI: 10.1016/j.arr.2022.101725

Abstract

The old people often suffer from circadian rhythm disturbances, which in turn accelerate aging. Many aging-related degenerative diseases such as Alzheimer's disease, Parkinson's disease, and osteoarthritis have an inextricable connection with circadian rhythm. In light of the predominant effects of clock genes on regulating circadian rhythm, we systematically present the elaborate network of roles that clock genes play in aging in this review. First, we briefly introduce the basic background regarding clock genes. Second, we systemically summarize the roles of clock genes in aging and aging-related degenerative diseases. Third, we discuss the relationship between clock genes polymorphisms and aging. In summary, this review is intended to clarify the indispensable roles of clock genes in aging and sheds light on developing clock genes as anti-aging targets.

Keywords: Aging; Alzheimer's disease; Clock genes; Genetic polymorphisms; Osteoarthritis; Parkinson's disease.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Aging* / genetics
Alzheimer Disease / genetics
CLOCK Proteins* / genetics
Circadian Rhythm* / genetics
Humans

Substances

CLOCK Proteins