Novel control strategies for the endocrine-disrupting effect of PAEs to pregnant women in traffic system

Abstract

Traffic-related air pollution has become a global issue, and scientific regulation measures are urgently needed to reduce traffic pollution. Phthalates (PAEs) have been widely detected in the traffic environment; thus, they were chosen as target pollutants because of their endocrine-disrupting effects. The pathways of action and mechanisms of PAEs' endocrine-disrupting effects in pregnant women through inhalation were deduced. A novel whole-process 1C + 3D + 5R regulation system was developed to control the endocrine-disrupting effect of PAEs on pregnant women based on the cleaning production concept. (1) For source reduction, the 2D-QSAR model of endocrine-disrupting effects of PAEs in pregnant women was constructed to screen out the key influencing factors as hydrogen bond interaction and hydrophobic interaction. Based on this, a designed PAE substitute molecule with low volatility and endocrine-disrupting effects and no developmental toxicity was screened. The substitute molecule could reduce the volatilization amount of PAEs at the source by 41.76 %; (2) For process interception, selecting C-band UV light to eliminate PAEs molecules in the traffic environment can slow down 19.99 % of the endocrine-disrupting effect of PAEs molecules. The homology modeling method was used to design four kinds of green belt plant proteins with high PAEs absorption efficiency to absorb PAEs molecules in the traffic environment. Compared with the original green belt plant proteins, the absorption amount of PAEs increased by up to 96.08 %, and (3) For terminal prevention, dietary food schemes were designed to regulate PAEs' endocrine-disrupting effect on pregnant women. The optimal dietary food scheme was the simultaneous intake of glutamate, catechin and folic acid, which could reduce the adverse effect of PAEs on maternal and infants by 32.51 %. This study presents theoretical support for regulating PAE exposure to specific populations in the traffic environment and treating other pollutants in the future.

Keywords: Cleaning production concept; Endocrine-disrupting control; Phthalates; Pregnant women and fetus; Traffic pollution.