Multi-parametric whole-body MRI evaluation discerns vital from non-vital multiple myeloma lesions as validated by 18F-FDG and 11C-methionine PET/CT

Abstract

Purpose: We tested a novel multi-parametric (mp) whole body (WB)-MRI evaluation algorithm for medullary lesions in comparison to positron emission tomography (PET) radiotracers ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) and ¹¹C-methionine (¹¹C-MET).

Methods and materials: This retrospective single-center study included 44 MM patients, who received both ¹⁸F-FDG-PET and WB-MRI within ten days. MRI classified focal lesions as vital when showing 1) significant diffusion-restriction, 2) a fat fraction (FF) less than 20 % and 3) homogenous hypointensity on T2-weighted images. On a lesion-by-lesion level the findings were compared to ¹⁸F-FDG PET by using a 5-point scoring system (analogous to the Deauville score [DS]). In 24/44 (55 %) patients additional comparison to ¹¹C-MET PET was available.

Results: Among two radiologists, an excellent inter-observer reliability for mpWB-MRI in a total of 84 medullary lesions was observed (ICC = 1, k = 1, p <.01). 16/17 (94.1 %) MRI-classified vital lesions had a DS of 4 or 5 on either ¹⁸F-FDG-PET or ¹¹C-MET-PET. MRI-rated non-vital lesions correlated with PET-based DS ≤ 3. When results of mpWB-MRI were compared to ¹⁸F-FDG, a fair inter-observer agreement was recorded (ICC = 0.52, k = 0.53, p <.01), while for ¹¹C-MET, an excellent concordance rate was achieved (ICC = 0.81, k = 0.79, p <.01).

Conclusion: The proposed mpWB-MRI interpretation algorithm allowed to assess tumor activity of myeloma lesions with high inter-observer reproducibility. We observed a substantial concordance between the mpWB-MRI classification of lesions and PET assessment based on a semi-automatically calculated 5-point scoring system analogous to the Deauville scores.

Keywords: (11)C-methionine; (18)F-FDG; Chemical shift imaging; Diffusion-weighted MRI; Fat fraction; Multi-parametric MRI; Multiple myeloma; PET; Positron emission tomography; Whole-body MRI.