Diagnosis of hepatic steatosis based on ultrasound attenuation imaging is not influenced by liver fibrosis

Minako Yuri; Takashi Nishimura; Toshifumi Tada; Masahiro Yoshida; Aoi Fujiwara; Shoki Kawata; Kohei Yoshihara; Ryota Yoshioka; Shogo Ota; Ryota Nakano; Yukihisa Yuri; Tomoyuki Takashima; Nobuhiro Aizawa; Naoto Ikeda; Hideyuki Shiomi; Yoshi-Hiro Ide; Hirayuki Enomoto; Fujimoto Yasuhiro; Hirohisa Yano; Hiroko Iijima

doi:10.1111/hepr.13831

Diagnosis of hepatic steatosis based on ultrasound attenuation imaging is not influenced by liver fibrosis

Hepatol Res. 2022 Dec;52(12):1009-1019. doi: 10.1111/hepr.13831. Epub 2022 Sep 9.

Authors

Minako Yuri¹, Takashi Nishimura^{1

2}, Toshifumi Tada³, Masahiro Yoshida², Aoi Fujiwara¹, Shoki Kawata¹, Kohei Yoshihara¹, Ryota Yoshioka¹, Shogo Ota¹, Ryota Nakano¹, Yukihisa Yuri¹, Tomoyuki Takashima¹, Nobuhiro Aizawa¹, Naoto Ikeda¹, Hideyuki Shiomi¹, Yoshi-Hiro Ide⁴, Hirayuki Enomoto¹, Fujimoto Yasuhiro⁵, Hirohisa Yano⁶, Hiroko Iijima^{1

2}

Affiliations

¹ Department of Gastroenterology and Hepatology, Hyogo Medical University, Nishinomiya, Japan.
² Ultrasound Imaging Center, Hyogo Medical University, Nishinomiya, Japan.
³ Department of Internal Medicine, Japanese Red Cross Society Himeji Hospital, Himeji, Japan.
⁴ Department of Pathology, Hyogo Medical University, Nishinomiya, Japan.
⁵ Department of Surgery, Hyogo Medical University, Nishinomiya, Japan.
⁶ Department of Pathology, Kurume University School of Medicine, Kurume, Japan.

PMID: 36018852
DOI: 10.1111/hepr.13831

Abstract

Aim: Recently, a new technique using attenuation imaging (ATI) was developed to diagnose hepatic steatosis. The aim of this study was to investigate whether ATI for the evaluation of hepatic steatosis is influenced by liver fibrosis.

Methods: A total of 328 patients with chronic liver disease were enrolled to study the associations between histological hepatic steatosis or liver fibrosis and ATI findings. The interaction between liver fibrosis and ATI was also analyzed.

Results: Median ATI values according to steatosis grade and fibrosis stage increased in line with the progression of liver steatosis (p < 0.001) and fibrosis (p < 0.05). However, in each steatosis grade, ATI values according to fibrosis stage were not significantly increased. In multiple regression analyses for assessment of the effect of their interaction, the p values for fibrosis stage, steatosis grade, and fibrosis stage × steatosis grade were 0.096, <0.001, and 0.077, respectively. Variance inflation factor values for fibrosis stage, steatosis grade, and fibrosis stage × steatosis grade were 1.079, 1.094, and 1.074, respectively.

Conclusion: Attenuation imaging values are not influenced by liver fibrosis.

Keywords: attenuation imaging; hepatic steatosis; interaction.

Abstract

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