Facile preparation of poly(N-isopropylacrylamide)/graphene oxide nanocomposites for chemo-photothermal therapy

Phornsawat Baipaywad; Naeun Ryu; Soo-Seok Im; Ukjae Lee; Hyung Bin Son; Won Jong Kim; Hansoo Park

doi:10.1080/15685551.2022.2111854

Facile preparation of poly(N-isopropylacrylamide)/graphene oxide nanocomposites for chemo-photothermal therapy

Des Monomers Polym. 2022 Aug 15;25(1):245-253. doi: 10.1080/15685551.2022.2111854. eCollection 2022.

Authors

Phornsawat Baipaywad^{1

2}, Naeun Ryu², Soo-Seok Im³, Ukjae Lee², Hyung Bin Son², Won Jong Kim³, Hansoo Park²

Affiliations

¹ Biomedical Engineering Institute, Chiang Mai University, Chiang Mai, Thailand.
² Department of Integrative Engineering, Chung-Ang University, Seoul, Republic of Korea.
³ Department of Chemistry, Pohang University of Science and Technology (POSTECH), Pohang, Republic of Korea.

Abstract

Carbon-based nanomaterials, such as carbon nanotubes, fullerenes, nanodiamonds, and graphene, have been investigated for various biomedical applications, including biological imaging, photothermal therapy, drug/gene delivery, cancer therapy, biosensors, and electrochemical sensors. Graphene oxide (GO) has unique physicochemical properties and can be used to restore conductivity through oxidation. In this study, we developed poly(N-isopropylacrylamide) (PNIPAM)-based nanogel systems containing GO for controlled in vitro drug delivery. The photothermal effects of the PNIPAM/GO- and PNIPAMAAM/GO-based nanogel systems were enhanced. The release of DOX from the PNIPAM/GO-based nanogel was achieved using the photothermal effect of near-infrared irradiation. Using a Cell Counting Kit-8 assay, the cytotoxicity of all conditions demonstrated that the PNIPAM composite-based nanogels were biocompatible with no significance.

Keywords: Poly(N-isopropylacrylamide); chemotherapy; graphene oxide; nanogel; photothermal therapy.

Grants and funding

This work was supported by Creative Materials Discovery Program through the National Research Foundation of Korea (NRF) funded by Ministry of Science and ICT(NRF-2018M3D1A1058813) and by a Chung-Ang University Research Scholarship Grant in 2020.