Advances in cell death mechanisms involved in viral myocarditis

Yang Yang; Wang Li; Benshuai You; Chenglin Zhou

doi:10.3389/fcvm.2022.968752

Advances in cell death mechanisms involved in viral myocarditis

Front Cardiovasc Med. 2022 Aug 9:9:968752. doi: 10.3389/fcvm.2022.968752. eCollection 2022.

Authors

Yang Yang^{1

2}, Wang Li^{1

2}, Benshuai You³, Chenglin Zhou^{1

2}

Affiliations

¹ Taizhou People's Hospital Affiliated to Nanjing Medical University, Taizhou, China.
² Clinical Laboratory Center, Jiangsu Taizhou People's Hospital, Taizhou, China.
³ School of Medicine, Jiangsu University, Zhenjiang, China.

Abstract

Viral myocarditis is an acute inflammatory disease of the myocardium. Although many etiopathogenic factors exist, coxsackievirus B3 is a the leading cause of viral myocarditis. Abnormal cardiomyocyte death is the underlying problem for most cardiovascular diseases and fatalities. Various types of cell death occur and are regulated to varying degrees. In this review, we discuss the different cell death mechanisms in viral myocarditis and the potential interactions between them. We also explore the role and mechanism of cardiomyocyte death with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Exploring the mechanisms may help in the early identification and the development of effective treatments, thus improving the quality of life of patients with viral myocarditis. We believe that the inhibition of cardiomyocyte death has immense therapeutic potential in increasing the longevity and health of the heart.

Keywords: CVB3; SARS-CoV-2; VMC; apoptosis; autophagy; ferroptosis; necrosis; pyroptosis.

Publication types

Review