PMMA Bone Cement: Antibiotic Elution and Mechanical Properties in the Context of Clinical Use

Sebastian Philipp von Hertzberg-Boelch; Martin Luedemann; Maximilian Rudert; Andre F Steinert

doi:10.3390/biomedicines10081830

PMMA Bone Cement: Antibiotic Elution and Mechanical Properties in the Context of Clinical Use

Biomedicines. 2022 Jul 29;10(8):1830. doi: 10.3390/biomedicines10081830.

Authors

Sebastian Philipp von Hertzberg-Boelch¹, Martin Luedemann¹, Maximilian Rudert¹, Andre F Steinert^{1

2}

Affiliations

¹ Department of Orthopaedic Surgery, University of Wuerzburg, Koenig-Ludwig-Haus, 11 Brettreichstrasse, 97074 Würzburg, Germany.
² Rhön Klinikum, Campus Bad Neustadt, EndoRhoen Center for Joint Replacement, Teaching Hospital of the Phillipps University Marburg, Von Guttenberg Str. 11, 97616 Bad Neustadt, Germany.

Abstract

This literature review discusses the use of antibiotic loaded polymethylmethacrylate bone cements in arthroplasty. The clinically relevant differences that have to be considered when antibiotic loaded bone cements (ALBC) are used either for long-term implant fixation or as spacers for the treatment of periprosthetic joint infections are outlined. In this context, in vitro findings for antibiotic elution and material properties are summarized and transferred to clinical use.

Keywords: PMMA; antibiotic elution; bone cement; periprosthetic infection; polymethylmethacrylate; spacer.

Publication types

Review

Grants and funding

This publication was supported by the Open Access Publication Fund of the University of Wuerzburg.