Quantitative Distribution of Cerebral Venous Oxygen Saturation and Its Prognostic Value in Patients with Acute Ischemic Stroke

Fengqiu Cao; Mingming Wang; Shanhua Han; Shengyu Fan; Yingwei Guo; Yingjian Yang; Yu Luo; Jia Guo; Yan Kang

doi:10.3390/brainsci12081109

Quantitative Distribution of Cerebral Venous Oxygen Saturation and Its Prognostic Value in Patients with Acute Ischemic Stroke

Brain Sci. 2022 Aug 20;12(8):1109. doi: 10.3390/brainsci12081109.

Authors

Fengqiu Cao^{1

2}, Mingming Wang³, Shanhua Han³, Shengyu Fan¹, Yingwei Guo^{1

2}, Yingjian Yang^{1

2}, Yu Luo³, Jia Guo⁴, Yan Kang^{1

2

5

6}

Affiliations

¹ College of Medicine and Biological Information Engineering, Northeastern University, Shenyang 110169, China.
² College of Health Science and Environmental Engineering, Shenzhen Technology University, Shenzhen 518118, China.
³ Department of Radiology, School of Medicine, Shanghai Fourth People's Hospital Affiliated to Tongji University, Shanghai 200434, China.
⁴ Department of Psychiatry, Columbia University, New York, NY 10027, USA.
⁵ Engineering Research Centre of Medical Imaging and Intelligent Analysis, Ministry of Education, Shenyang 110169, China.
⁶ School of Applied Technology, Shenzhen University, Shenzhen 518060, China.

Abstract

This study investigated the quantitative distribution of cerebral venous oxygen saturation (SvO2) based on quantitative sensitivity mapping (QSM) and determined its prognostic value in patients with acute ischemic stroke (AIS). A retrospective study was conducted on 39 hospitalized patients. Reconstructed QSM was used to calculate the cerebral SvO2 of each region of interest (ROI) in the ischemic hemisphere. The intraclass correlation coefficient (ICC) and Bland−Altman analysis were conducted to define the best resolution of the distribution map. The correlation between the cerebral SvO2 in hypoxic regions (SvO2ROI < 0.7) and clinical scores was obtained by Spearman and power analysis. The associations between cerebral SvO2 and unfavorable prognosis were analyzed using multivariate logistic regression. Excellent agreement was found between the cerebral SvO2 in hypoxic regions with a resolution of 7.18 × 7.18 × 1.6 mm3 and asymmetrically prominent cortical veins regions (ICC: 0.879 (admission), ICC: 0.906 (discharge)). The cerebral SvO2 was significantly negative with clinical scores (all |r| > 0.3). The cerebral SvO2 and its changes at discharge were significantly associated with an unfavorable prognosis (OR: 0.812 and 0.866). Therefore, the cerebral SvO2 in hypoxic regions measured by the quantitative distribution map can be used as an indicator for evaluating the early prognosis of AIS.

Keywords: acute ischemic stroke; cerebral venous oxygen saturation; hypoxic regions; prognosis; quantitative distribution.

Grants and funding

This study was funded by the Natural Scientific Foundation of China (81971590 and 62071311), the Natural Science Foundation of Guangdong Province, China (2019A1515011382), the Stable Support Plan for Colleges and Universities in Shenzhen, China (SZWD2021010), the Scientific Research Fund of Liaoning Province, China (JL201919), and the special program for key fields of colleges and universities in Guangdong Province (biomedicine and health) of China (2021ZDZX2008).