From an EtOAc-soluble fraction of the roots of Paramignya trimera, one undescribed chromene derivative, paratrimerin Z (1), was isolated. Its structure was elucidated on the basis of NMR spectroscopic interpretation. The absolute configuration of 1 was determined by the specific rotation analysis of its acid-catalyzed hydrolysis product. Paratrimerin Z (1), at a concentration of 100 μM, did not show cytotoxicity against Hep3B human liver cancer cell line.
Keywords: Hep3B cytotoxicity; Paramignya trimera; chromene.