Kawasaki disease and MIS-C share a host immune response

Paul Tsoukas; Rae S M Yeung

doi:10.1038/s41584-022-00820-5

Kawasaki disease and MIS-C share a host immune response

Nat Rev Rheumatol. 2022 Oct;18(10):555-556. doi: 10.1038/s41584-022-00820-5.

Authors

Paul Tsoukas¹, Rae S M Yeung^{2

3}

Affiliations

¹ Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada.
² Division of Rheumatology, The Hospital for Sick Children, Toronto, ON, Canada. rae.yeung@sickkids.ca.
³ Department of Immunology and Institute of Medical Science, University of Toronto, Toronto, ON, Canada. rae.yeung@sickkids.ca.

Abstract

Multisystem inflammatory syndrome in children (MIS-C) and Kawasaki disease are both hyperinflammatory disorders associated with infectious diseases, but are they distinct syndromes or do they exist along a continuum? A comparison of the host immune response in these illnesses provides surprising new insights.

Publication types

Research Support, Non-U.S. Gov't
Comment

MeSH terms

COVID-19* / complications
Humans
Immunity
Mucocutaneous Lymph Node Syndrome*
Systemic Inflammatory Response Syndrome

Supplementary concepts

pediatric multisystem inflammatory disease, COVID-19 related