Research progress of m6A regulation during animal growth and development

Yu Hengwei; Sayed Haidar Abbas Raza; Zhang Wenzhen; Yang Xinran; Hailah M Almohaimeed; Aliah R Alshanwani; Rasha Assiri; Waheeb S Aggad; Linsen Zan

doi:10.1016/j.mcp.2022.101851

Research progress of m⁶A regulation during animal growth and development

Mol Cell Probes. 2022 Oct:65:101851. doi: 10.1016/j.mcp.2022.101851. Epub 2022 Aug 23.

Authors

Yu Hengwei¹, Sayed Haidar Abbas Raza², Zhang Wenzhen³, Yang Xinran³, Hailah M Almohaimeed⁴, Aliah R Alshanwani⁵, Rasha Assiri⁶, Waheeb S Aggad⁷, Linsen Zan⁸

Affiliations

¹ College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. Electronic address: yuhengwei@nwafu.edu.cn.
² College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China. Electronic address: dr.haiderabbasraza@gmail.com.
³ College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China.
⁴ Department of Basic Science, College of Medicine, Princess Nourah Bint Abdulrahman University, P.O.Box 84428, Riyadh, 11671, Saudi Arabia.
⁵ Physiology Department, College of Medicine, King Saud University, Saudi Arabia.
⁶ Department of Basic Medical Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, 11671, Saudi Arabia.
⁷ Department of Anatomy, College of Medicine, University of Jeddah, P.O.Box 8304, Jeddah, 23234, Saudi Arabia.
⁸ College of Animal Science and Technology, Northwest A&F University, Yangling, 712100, China; National Beef Cattle Improvement Center, Yangling, 712100, China. Electronic address: zanlinsen@163.com.

PMID: 36007750
DOI: 10.1016/j.mcp.2022.101851

Abstract

Environmental factors, genetic factors, and epigenetics are involved in animal growth and development. Among them, methylation is one of the abundant modifications of epigenetics. N6-methyladenosine(m⁶A) is extensive in cellular RNA, of which mRNA is the most common internal modification. m⁶A modification regulates life activities dynamically and reversibly, including expressed genes, RNA metabolism, and protein translation. The m⁶A modifications are closely related to human diseases involving heart failure, tumors, and cancer. It is relatively in-depth in the medical field. However, there are few studies on its biochemical function in animals. We summarized the latest paper related to the chemical structure and role of the writers, the erasers, and the readers to study exerting dynamic regulation of m⁶A modification of animal growth and development. Furthermore, the key roles of m⁶A modification were reported in the process of RNA metabolism. Finally, the dynamic regulation of m⁶A modification in animal growth and development was reviewed, including brain development, fertility, fat deposition, and muscle production. It reveals the key roles of m⁶A modification and the regulation of gene expression, aiming to provide new ideas for m⁶A methylation in animal growth and development.

Keywords: Animal growth and development; RNA metabolism; m(6)A methylation.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Adenosine* / genetics
Adenosine* / metabolism
Animals
Growth and Development / genetics
Humans
Methylation
Neoplasms* / genetics
RNA / metabolism
RNA, Messenger / genetics

Substances

RNA, Messenger
RNA
Adenosine