Membrane-Coated Biomimetic Nanoparticles: A State-of-the-Art Multifunctional Weapon for Tumor Immunotherapy

Yuanyuan Zhang; Xinyi Zhang; Haitao Li; Jianyong Liu; Wei Wei; Jie Gao

doi:10.3390/membranes12080738

Membrane-Coated Biomimetic Nanoparticles: A State-of-the-Art Multifunctional Weapon for Tumor Immunotherapy

Membranes (Basel). 2022 Jul 28;12(8):738. doi: 10.3390/membranes12080738.

Authors

Yuanyuan Zhang¹, Xinyi Zhang², Haitao Li³, Jianyong Liu³, Wei Wei¹, Jie Gao¹

Affiliations

¹ Changhai Clinical Research Unit, Shanghai Changhai Hospital, Naval Medical University, Shanghai 200433, China.
² Institute of Translational Medicine, Shanghai University, Shanghai 200444, China.
³ Department of Vascular Surgery, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefangdadao Road, Wuhan 430022, China.

Abstract

The advent of immunotherapy, which improves the immune system's ability to attack and eliminate tumors, has brought new hope for tumor treatment. However, immunotherapy regimens have seen satisfactory results in only some patients. The development of nanotechnology has remarkably improved the effectiveness of tumor immunotherapy, but its application is limited by its passive immune clearance, poor biocompatibility, systemic immunotoxicity, etc. Therefore, membrane-coated biomimetic nanoparticles have been developed by functional, targeting, and biocompatible cell membrane coating technology. Membrane-coated nanoparticles have the advantages of homologous targeting, prolonged circulation, and the avoidance of immune responses, thus remarkably improving the therapeutic efficacy of tumor immunotherapy. Herein, this review explores the recent advances and future perspectives of cell membrane-coated nanoparticles for tumor immunotherapy.

Keywords: biomimetic nanoparticles; cell membrane coating; drug delivery; tumor immunotherapy.

Publication types

Review

Grants and funding

This study was performed under the support of the National Natural Science Foundation of China (Project number: 81771964, 82072051, 81903233, 81874250 and 81800991).