An Efficient Method for the Preparation of Sulfonamides from Sodium Sulfinates and Amines

Haiying Tian; Ruiyan Li; Fang Guo; Xiuling Chen

doi:10.1002/open.202200097

An Efficient Method for the Preparation of Sulfonamides from Sodium Sulfinates and Amines

ChemistryOpen. 2022 Aug;11(8):e202200097. doi: 10.1002/open.202200097.

Authors

Haiying Tian¹, Ruiyan Li¹, Fang Guo², Xiuling Chen²

Affiliations

¹ Department of Pharmacy, Changzhi Medical College, 046000, Changzhi, P. R. China.
² Department of Materials Science and Engineering, Jinzhong University, 030619, Jinzhong, P. R. China.

Abstract

Sulfonamides have a special role on medicine due to their broad biological activities, as bacterial infections, diabetes mellitus, oedema, hypertension prevention and treatment. In addition, sulfonamides are also useful in herbicides and pesticides. Herein, we communicate an efficient strategy for the preparation of sulfonamides via NH₄ I-mediated amination of sodium sulfinates. This new method provides a general and environmentally friendly access to sulfonamide compounds and tolerates a wide range of functional groups.

Keywords: NH4I; green protocols; metal-free; sodium sulfinates; sulfonamides.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Amination
Amines*
Molecular Structure
Sodium
Sulfanilamide
Sulfonamides*

Substances

Amines
Sulfonamides
Sulfanilamide
Sodium