Association between sequential extreme precipitation-heatwaves events and hospitalizations for schizophrenia: The damage amplification effects of sequential extremes

Jintao Liu; Wenping Yu; Rubing Pan; Yangyang He; Yudong Wu; Shuangshuang Yan; Weizhuo Yi; Xuanxuan Li; Rong Song; Jiajun Yuan; Li Liu; Ning Wei; Xiaoyu Jin; Yuxuan Li; Yunfeng Liang; Xiaoni Sun; Lu Mei; Jian Song; Jian Cheng; Hong Su

doi:10.1016/j.envres.2022.114143

Association between sequential extreme precipitation-heatwaves events and hospitalizations for schizophrenia: The damage amplification effects of sequential extremes

Environ Res. 2022 Nov;214(Pt 4):114143. doi: 10.1016/j.envres.2022.114143. Epub 2022 Aug 22.

Authors

Jintao Liu¹, Wenping Yu², Rubing Pan¹, Yangyang He¹, Yudong Wu¹, Shuangshuang Yan¹, Weizhuo Yi¹, Xuanxuan Li¹, Rong Song¹, Jiajun Yuan¹, Li Liu¹, Ning Wei¹, Xiaoyu Jin¹, Yuxuan Li¹, Yunfeng Liang¹, Xiaoni Sun¹, Lu Mei¹, Jian Song¹, Jian Cheng¹, Hong Su³

Affiliations

¹ Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Disease, China.
² Department of Geriatrics, Shandong Daizhuang Hospital, China.
³ Department of Epidemiology and Health Statistics, School of Public Health, Anhui Medical University, Hefei, Anhui, 230032, China; Anhui Province Key Laboratory of Major Autoimmune Disease, China. Electronic address: suhong5151@sina.com.

PMID: 35998693
DOI: 10.1016/j.envres.2022.114143

Abstract

Objectives: In the context of frequent global extreme weather events, there are few studies on the effects of sequential extreme precipitation (EP) and heatwaves (HW) events on schizophrenia. We aimed to quantify the effects of the events on hospitalizations for schizophrenia and compare them with EP and HW alone to explore the amplification effect of successive extremes on health loss.

Methods: A time-series Poisson regression model combined with a distributed lag non-linear model was applied to estimate the association between sequential EP and HW events (EP-HW) and schizophrenia hospitalizations. The effects of EP-HW with different intervals and intensities on the admission of schizophrenia were compared. In addition, we calculated the mean attributable fraction (AF) and attributable numbers (AN) per exposure of extreme events to reflect the amplification effect of sequential extreme events on health hazards compared with individual extreme events.

Results: EP-HW increased the risk of hospitalization for schizophrenia, with significant effects lasting from lag0 (RR and 95% CI: 1.150 (1.041-1.271)) to lag11 (1.046 (1.000-1.094)). Significant associations were found in the subgroups of male, female, married people, and those aged≥ 40 years old. Shorter-interval (0-3days) or higher-intensity EP-HW (both precipitation ≥ P97.5 and mean temperature ≥ P97.5) had a longer lag effect compared to EP-HW with longer intervals or lower intensity. We found that the mean AF and AN caused by each exposure to EP-HW (AF: 0.074% (0.015%-0.123%); AN: 4.284 (0.862-7.118)) were higher than those induced by each exposure to HW occurring alone (AF:0.032% (0.004%-0.058%); AN:1.845 (0.220-3.329)).

Conclusions: Sequential extreme precipitation-heatwaves events significantly increase the risk of hospitalizations for schizophrenia, with greater impact and disease burden than independently occurring extremes. The impact of consecutive extremes is supposed to be considered in local sector early warning systems for comprehensive public health decision-making.

Keywords: Damage amplification; Extreme precipitation; Heatwaves; Schizophrenia; Sequential.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Cost of Illness
Female
Hospitalization
Humans
Male
Schizophrenia* / epidemiology
Temperature
Time Factors