Clinical Features of Neurodevelopmental Outcomes in Children with Preterm Severe Fetal Growth Restriction: A Retrospective Observational Study

Takahiro Motoki; Yoshitsugu Chigusa; Seiichi Tomotaki; Yosuke Kawamura; Mana Taki; Ken Yamaguchi; Masaki Mandai; Haruta Mogami

doi:10.31662/jmaj.2022-0047

Clinical Features of Neurodevelopmental Outcomes in Children with Preterm Severe Fetal Growth Restriction: A Retrospective Observational Study

JMA J. 2022 Jul 15;5(3):341-348. doi: 10.31662/jmaj.2022-0047. Epub 2022 Jun 17.

Authors

Takahiro Motoki¹, Yoshitsugu Chigusa¹, Seiichi Tomotaki², Yosuke Kawamura¹, Mana Taki¹, Ken Yamaguchi¹, Masaki Mandai¹, Haruta Mogami¹

Affiliations

¹ Department of Gynecology and Obstetrics, Kyoto University, Kyoto, Japan.
² Department of Pediatrics, Kyoto University, Kyoto, Japan.

Abstract

Introduction: Fetal growth restriction (FGR) is a clinical condition wherein a fetus fails to achieve the expected growth potential. Although FGR is the leading cause of perinatal morbidity and mortality, there is a lack of knowledge about the long-term developmental outcomes of children who had FGR in Japan. Here, we sought to clarify the features of neurodevelopmental outcomes in preterm-born children with severe FGR (sFGR) and identify associated clinical factors.

Methods: The clinical data of 26 preterm sFGR cases and 26 preterm appropriate for gestational age (AGA) cases with a similar gestational age distribution were reviewed retrospectively. Developmental quotient (DQ) scores assessed during the 1- and 2-year corrected ages using the Kyoto Scale of Psychological Development were analyzed.

Results: sFGR was diagnosed at 26 (18-34) weeks of gestation, and the gestational age at delivery was 31 (25-36) weeks. The overall DQ scores of children in the sFGR group were significantly lower than those in the AGA group (80 vs. 90.5, P = 0.0127). Of the three areas that comprise the DQ (Postural-Motor, Cognitive-Adaptive, and Language-Social), the sFGR group only showed significantly lower DQ scores (72.5 vs. 88, P = 0.0255) in the Language-Social area. Both fetal body weight and fetal body weight Z score at birth significantly correlated with the DQ scores (r = 0.4912, P = 0.0108, and r = 0.5621, P = 0.0028), whereas neither the duration of fetal growth arrest nor the gestational age at birth correlated with the DQ scores (r = 0.3598, P = 0.0842, and r = 0.3522, P = 0.0776).

Conclusions: Our results indicate that preterm-born children with sFGR have greater neurodevelopmental impairment than preterm-born children without FGR, specifically in terms of the DQ scores for the Language-Social area. It is imperative to encourage continuous long-term follow-up and appropriate interventions after birth.

Keywords: developmental quotient; fetal growth restriction; neurodevelopment; preterm birth; small for gestational age.