Long noncoding RNAs (lncRNAs) in HIV-mediated carcinogenesis: Role in cell homeostasis, cell survival processes and drug resistance

Lilian Makgoo; Salerwe Mosebi; Zukile Mbita

doi:10.1016/j.ncrna.2022.07.003

Long noncoding RNAs (lncRNAs) in HIV-mediated carcinogenesis: Role in cell homeostasis, cell survival processes and drug resistance

Noncoding RNA Res. 2022 Jul 31;7(3):184-196. doi: 10.1016/j.ncrna.2022.07.003. eCollection 2022 Sep.

Authors

Lilian Makgoo¹, Salerwe Mosebi², Zukile Mbita¹

Affiliations

¹ University of Limpopo, Department of Biochemistry, Microbiology and Biotechnology, Private Bag X 1106, Sovenga, 0727, Polokwane, South Africa.
² Department of Life and Consumer Sciences, University of South Africa, Private Bag X06, Florida, 1710, South Africa.

Abstract

There is accruing data implicating long non-coding RNAs (lncRNAs) in the development and progression of non-communicable diseases such as cancer. These lncRNAs have been implicated in many diverse HIV-host interactions, some of which are beneficial to HIV propagation. The virus-host interactions induce the expression of HIV-regulated long non-coding RNAs, which are implicated in the carcinogenesis process, therefore, it is critical to understand the molecular mechanisms that underpin these HIV-regulated lncRNAs, especially in cancer formation. Herein, we summarize the role of HIV-regulated lncRNAs targeting cancer development-related processes including apoptosis, cell cycle, cell survival signalling, angiogenesis and drug resistance. It is unclear how lncRNAs regulate cancer development, this review also discuss recent discoveries regarding the functions of lncRNAs in cancer biology. Innovative research in this field will be beneficial for the future development of therapeutic strategies targeting long non-coding RNAs that are regulated by HIV, especially in HIV associated cancers.

Keywords: Carcinogenesis; Cellular process; Drug resistance; HIV-1 • long non-coding RNA; Oncogenic virus.

Publication types

Review