Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases

Zhengping Che; Ziyu Ye; Xueying Zhang; Bihua Lin; Weiqing Yang; Yanfang Liang; Jincheng Zeng

doi:10.3389/fimmu.2022.952071

Mesenchymal stem/stromal cells in the pathogenesis and regenerative therapy of inflammatory bowel diseases

Front Immunol. 2022 Aug 4:13:952071. doi: 10.3389/fimmu.2022.952071. eCollection 2022.

Authors

Zhengping Che^{1

2

3}, Ziyu Ye^{1

3}, Xueying Zhang^{1

3}, Bihua Lin^{1

4

5}, Weiqing Yang^{1

3}, Yanfang Liang^{1

2}, Jincheng Zeng^{1

4

5

6}

Affiliations

¹ Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Guangdong Medical University, Dongguan, China.
² Department of Pathology, Dongguan Hospital Affiliated to Jinan University, Binhaiwan Central Hospital of Dongguan, Dongguan, China.
³ Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, School of Medical Technology, Guangdong Medical University, Dongguan, China.
⁴ Key Laboratory of Medical Bioactive Molecular Research for Department of Education of Guangdong Province, School of Basic Medicine, Guangdong Medical University, Dongguan, China.
⁵ Collaborative Innovation Center for Antitumor Active Substance Research and Development, Department of Biochemistry and Molecular Biology, School of Basic Medicine, Guangdong Medical University, Zhanjiang, China.
⁶ Dongguan Metabolite Analysis Engineering Technology Center of Cells for Medical Use, Guangdong Xinghai Institute of Cell, Dongguan, China.

Abstract

Inflammatory bowel diseases (IBDs) represent a group of chronic inflammatory disorders of the gastrointestinal (GI) tract including ulcerative colitis (UC), Crohn's disease (CD), and unclassified IBDs. The pathogenesis of IBDs is related to genetic susceptibility, environmental factors, and dysbiosis that can lead to the dysfunction of immune responses and dysregulated homeostasis of local mucosal tissues characterized by severe inflammatory responses and tissue damage in GI tract. To date, extensive studies have indicated that IBDs cannot be completely cured and easy to relapse, thus prompting researchers to find novel and more effective therapeutics for this disease. Due to their potent multipotent differentiation and immunomodulatory capabilities, mesenchymal stem/stromal cells (MSCs) not only play an important role in regulating immune and tissue homeostasis but also display potent therapeutic effects on various inflammatory diseases, including IBDs, in both preclinical and clinical studies. In this review, we present a comprehensive overview on the pathological mechanisms, the currently available therapeutics, particularly, the potential application of MSCs-based regenerative therapy for IBDs.

Keywords: Crohn’s disease; inflammatory bowel diseases; mesenchymal stem/stromal cells; regenerative therapy; ulcerative colitis.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Colitis, Ulcerative*
Crohn Disease* / therapy
Humans
Inflammatory Bowel Diseases* / etiology
Inflammatory Bowel Diseases* / therapy
Mesenchymal Stem Cell Transplantation*
Mesenchymal Stem Cells*