Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets

Mumtaza Mumu; Ayan Das; Talha Bin Emran; Saikat Mitra; Fahadul Islam; Arpita Roy; Md Mobarak Karim; Rajib Das; Moon Nyeo Park; Deepak Chandran; Rohit Sharma; Mayeen Uddin Khandaker; Abubakr M Idris; Bonglee Kim

doi:10.3389/fphar.2022.929442

Fucoxanthin: A Promising Phytochemical on Diverse Pharmacological Targets

Front Pharmacol. 2022 Aug 2:13:929442. doi: 10.3389/fphar.2022.929442. eCollection 2022.

Authors

Mumtaza Mumu¹, Ayan Das¹, Talha Bin Emran^{2

3}, Saikat Mitra⁴, Fahadul Islam³, Arpita Roy⁵, Md Mobarak Karim⁶, Rajib Das³, Moon Nyeo Park⁷, Deepak Chandran⁸, Rohit Sharma⁹, Mayeen Uddin Khandaker¹⁰, Abubakr M Idris^{11

12}, Bonglee Kim⁷

Affiliations

¹ Department of Biochemistry and Molecular Biology, Faculty of Biological Sciences, University of Chittagong, Chittagong, Bangladesh.
² Department of Pharmacy, BGC Trust University Bangladesh, Chittagong, Bangladesh.
³ Department of Pharmacy, Faculty of Allied Health Sciences, Daffodil International University, Dhaka, Bangladesh.
⁴ Department of Pharmacy, Faculty of Pharmacy, University of Dhaka, Dhaka, Bangladesh.
⁵ Department of Biotechnology, School of Engineering and Technology, Sharda University, Greater Noida, India.
⁶ Department of Biomedical Engineering, University of Houston, Houston, TX, United States.
⁷ Department of Pathology College of Korean Medicine, Kyung Hee University, Seoul, South Korea.
⁸ Department of Veterinary Sciences and Animal Husbandry, Amrita School of Agricultural Sciences, Amrita Vishwa Vidyapeetham University, Coimbatore, India.
⁹ Department of Rasa Shastra and Bhaishajya Kalpana, Faculty of Ayurveda, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
¹⁰ Centre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Bandar Sunway, Malaysia.
¹¹ Department of Chemistry, College of Science, King Khalid University, Abha, Saudi Arabia.
¹² Research Center for Advanced Materials Science (RCAMS), King Khalid University, Abha, Saudi Arabia.

Abstract

Fucoxanthin (FX) is a special carotenoid having an allenic bond in its structure. FX is extracted from a variety of algae and edible seaweeds. It has been proved to contain numerous health benefits and preventive effects against diseases like diabetes, obesity, liver cirrhosis, malignant cancer, etc. Thus, FX can be used as a potent source of both pharmacological and nutritional ingredient to prevent infectious diseases. In this review, we gathered the information regarding the current findings on antimicrobial, antioxidant, anti-inflammatory, skin protective, anti-obesity, antidiabetic, hepatoprotective, and other properties of FX including its bioavailability and stability characteristics. This review aims to assist further biochemical studies in order to develop further pharmaceutical assets and nutritional products in combination with FX and its various metabolites.

Keywords: anti-inflammatory activity; anticancer activity; antimicrobial activity; enzyme inhibition; fucoxanthin; phytochemicals.

Publication types

Review