Emerging role of non-coding RNAs in glucose metabolic reprogramming and chemoresistance in colorectal cancer

Shushan Yan; Shufeng Wang; Xinyi Wang; Wenqing Dai; Jinjin Chu; Min Cheng; Zhiliang Guo; Donghua Xu

doi:10.3389/fonc.2022.954329

Emerging role of non-coding RNAs in glucose metabolic reprogramming and chemoresistance in colorectal cancer

Front Oncol. 2022 Aug 1:12:954329. doi: 10.3389/fonc.2022.954329. eCollection 2022.

Authors

Shushan Yan¹, Shufeng Wang², Xinyi Wang³, Wenqing Dai⁴, Jinjin Chu⁴, Min Cheng⁵, Zhiliang Guo⁶, Donghua Xu^{4

7}

Affiliations

¹ Department of Gastrointestinal and Anal Diseases Surgery of the Affiliated Hospital, Weifang Medical University, Weifang, China.
² Medical Experimental Training Center, Weifang Medical University, Weifang, China.
³ Clinical Medicine of Basic Medical School, Shandong First Medical University, Jinan, China.
⁴ Central Laboratory of the First Affiliated Hospital, Weifang Medical University, Weifang, China.
⁵ Department of Physiology, Weifang Medical University, Weifang, China.
⁶ Department of Spine Surgery, The 80th Group Army Hospital of Chinese People's Liberation Army (PLA), Weifang, China.
⁷ Department of Rheumatology of the First Affiliated Hospital, Weifang Medical University, Weifang, China.

Abstract

Metabolic reprogramming plays a critical role in colorectal cancer (CRC). It contributes to CRC by shaping metabolic phenotypes and causing uncontrolled proliferation of CRC cells. Glucose metabolic reprogramming is common in carcinogenesis and cancer progression. Growing evidence has implicated the modifying effects of non-coding RNAs (ncRNAs) in glucose metabolic reprogramming and chemoresistance in CRC. In this review, we have summarized currently published studies investigating the role of ncRNAs in glucose metabolic alterations and chemoresistance in CRC. Elucidating the interplay between ncRNAs and glucose metabolic reprogramming provides insight into exploring novel biomarkers for the diagnosis and prognosis prediction of CRC.

Keywords: Circular RNA; colorectal cancer; glucose metabolism; long noncoding RNA; metabolic reprogramming; microRNA.

Publication types

Review