Molecular data storage with zero synthetic effort and simple read-out

Sci Rep. 2022 Aug 16;12(1):13878. doi: 10.1038/s41598-022-18108-9.

Abstract

Compound mixtures represent an alternative, additional approach to DNA and synthetic sequence-defined macromolecules in the field of non-conventional molecular data storage, which may be useful depending on the target application. Here, we report a fast and efficient method for information storage in molecular mixtures by the direct use of commercially available chemicals and thus, zero synthetic steps need to be performed. As a proof of principle, a binary coding language is used for encoding words in ASCII or black and white pixels of a bitmap. This way, we stored a 25 × 25-pixel QR code (625 bits) and a picture of the same size. Decoding of the written information is achieved via spectroscopic (1H NMR) or chromatographic (gas chromatography) analysis. In addition, for a faster and automated read-out of the data, we developed a decoding software, which also orders the data sets according to an internal "ordering" standard. Molecular keys or anticounterfeiting are possible areas of application for information-containing compound mixtures.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • DNA / genetics
  • Datasets as Topic / statistics & numerical data
  • Information Storage and Retrieval* / methods
  • Information Storage and Retrieval* / standards
  • Magnetic Resonance Spectroscopy
  • Software*

Substances

  • DNA