Current advancements and future perspectives of long noncoding RNAs in lipid metabolism and signaling

Jiufei Duan; Zhao Huang; Edouard C Nice; Na Xie; Mingqing Chen; Canhua Huang

doi:10.1016/j.jare.2022.08.007

Current advancements and future perspectives of long noncoding RNAs in lipid metabolism and signaling

J Adv Res. 2023 Jun:48:105-123. doi: 10.1016/j.jare.2022.08.007. Epub 2022 Aug 13.

Authors

Jiufei Duan¹, Zhao Huang¹, Edouard C Nice², Na Xie³, Mingqing Chen⁴, Canhua Huang⁵

Affiliations

¹ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, 610041 Chengdu, China.
² Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, Australia.
³ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, 610041 Chengdu, China. Electronic address: naxie@scu.edu.cn.
⁴ Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, 430079 Wuhan, China. Electronic address: chenmq@mail.ccnu.edu.cn.
⁵ State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, and Collaborative Innovation Center for Biotherapy, 610041 Chengdu, China. Electronic address: hcanhua@scu.edu.cn.

Abstract

Background: The investigation of lncRNAs has provided a novel perspective for elucidating mechanisms underlying diverse physiological and pathological processes. Compelling evidence has revealed an intrinsic link between lncRNAs and lipid metabolism, demonstrating that lncRNAs-induced disruption of lipid metabolism and signaling contribute to the development of multiple cancers and some other diseases, including obesity, fatty liver disease, and cardiovascular disease.

Aimof review: The current review summarizes the recent advances in basic research about lipid metabolism and lipid signaling-related lncRNAs. Meanwhile, the potential and challenges of targeting lncRNA for the therapy of cancers and other lipid metabolism-related diseases are also discussed.

Key scientific concept of review: Compared with the substantial number of lncRNA loci, we still know little about the role of lncRNAs in metabolism. A more comprehensive understanding of the function and mechanism of lncRNAs may provide a new standpoint for the study of lipid metabolism and signaling. Developing lncRNA-based therapeutic approaches is an effective strategy for lipid metabolism-related diseases.

Keywords: Lipid chaperones; Lipid metabolism; Lipid receptors; Long noncoding RNAs; Therapeutic target.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Lipid Metabolism / genetics
Metabolic Diseases*
Neoplasms* / genetics
Neoplasms* / therapy
Non-alcoholic Fatty Liver Disease*
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism

Substances

RNA, Long Noncoding