Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus

Tong Wang; Ling Xu; Bin Zhu; Junzhong Wang; Xin Zheng

doi:10.3389/fimmu.2022.937684

Immune escape mechanisms of severe fever with thrombocytopenia syndrome virus

Front Immunol. 2022 Jul 28:13:937684. doi: 10.3389/fimmu.2022.937684. eCollection 2022.

Authors

Tong Wang^{1

2}, Ling Xu^{1

2}, Bin Zhu^{1

2}, Junzhong Wang^{1

2}, Xin Zheng^{1

2}

Affiliations

¹ Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
² Joint International Laboratory of Infection and Immunity, Huazhong University of Science and Technology, Wuhan, China.

Abstract

Severe fever with thrombocytopenia syndrome (SFTS), which is caused by SFTS virus (SFTSV), poses a serious threat to global public health, with high fatalities and an increasing prevalence. As effective therapies and prevention strategies are limited, there is an urgent need to elucidate the pathogenesis of SFTS. SFTSV has evolved several mechanisms to escape from host immunity. In this review, we summarize the mechanisms through which SFTSV escapes host immune responses, including the inhibition of innate immunity and evasion of adaptive immunity. Understanding the pathogenesis of SFTS will aid in the development of new strategies for the treatment of this disease.

Keywords: SFTS; SFTSV; adaptive immune response; immune escape; innate immune response.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Bunyaviridae Infections*
Humans
Immunity, Innate
Phlebovirus*
Severe Fever with Thrombocytopenia Syndrome*

Supplementary concepts

SFTS phlebovirus