Effects and Safety of Traditional Chinese Medicine for Hidden Blood Loss after Total Hip Arthroplasty-A Systematic Review and Meta-Analysis

Ze Yang; Xiang Wang; Zheyun Xu; Qike Xu; Yongliang Xia; Weifeng Ji

doi:10.1155/2022/6937295

Effects and Safety of Traditional Chinese Medicine for Hidden Blood Loss after Total Hip Arthroplasty-A Systematic Review and Meta-Analysis

Evid Based Complement Alternat Med. 2022 Aug 5:2022:6937295. doi: 10.1155/2022/6937295. eCollection 2022.

Authors

Ze Yang¹, Xiang Wang², Zheyun Xu³, Qike Xu⁴, Yongliang Xia⁵, Weifeng Ji⁶

Affiliations

¹ The First Clinical Medical College, Zhejiang Traditional Chinese Medical University, Hangzhou 310053, China.
² Department of Orthopedics, Tongde Hospital of Zhejiang Province, Hangzhou 310012, China.
³ The Fourth Clinical Medical College, Zhejiang Traditional Chinese Medical University, Hangzhou 310053, China.
⁴ Department of Traditional Chinese Medicine, Hangzhou Zelin Health Management Co. Ltd., Neighborhood Good Doctor No. 6 Street Clinic, Hangzhou 310000, Zhejiang, China.
⁵ Department of Internal Traditional Chinese Medicine, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang, China.
⁶ Department of Orthopedics, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou 310006, Zhejiang, China.

Abstract

Background: Hidden blood loss (HBL) after total hip arthroplasty (THA) would lead to many undesirable consequences. Traditional Chinese medicine (TCM) is now increasingly used for hidden blood loss. We performed this systematic review and meta-analysis to summarize the effect and safety of TCM treatment of HBL after THA.

Methods: We searched PubMed, Embase, Cochrane Library, CNKI, VIP, WanFang, and CBM for the updated articles published from the inception of each database to May, 2022, among which results such as abstracts, comments, letters, reviews, and case reports were excluded. The efficacy and safety of TCM treatment of HBL after THA were synthesized and discussed by the outcomes of total blood loss (TBL), hidden blood loss (HBL), hemoglobin (Hb), and hematocrit (HCT), and the incidence of adverse reactions.

Results: A total of 12 articles and 881 patients were included. There were 441 cases in the intervention group and 440 cases in the control group. Compared with the control group, the intervention group had more advantages in TBL (MD = -251.68, 95% CI = [-378.36, -125]; Z = 3.89, P < 0.00001), HBL (MD = -159.64, 95% CI = [-252.56, -66.71]; Z = 3.37, P=0.0008), Hb (MD = 11.39, 95% CI = [7.35, 15.43]; Z = 5.53, P < 0.00001), and HCT (MD = 2.87, 95% CI = [0.97, 4.78]; Z = 2.95, P=0.003), and had less incidence of adverse reactions (OR = -0.20, 95% CI = [-0.35, -0.05]; Z = 2.64, P=0.008).

Conclusion: TCM has advantages in the efficacy and safety of treating hidden blood loss after THA. The strength of the evidence of the research results is limited by the quality of the included literature, and more high-quality RCTs are needed to confirm.

Publication types

Review