The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders

Yi Liu; Yingting Wu; Mengxi Jiang

doi:10.3389/fphys.2022.935195

The emerging roles of PHOSPHO1 and its regulated phospholipid homeostasis in metabolic disorders

Front Physiol. 2022 Jul 26:13:935195. doi: 10.3389/fphys.2022.935195. eCollection 2022.

Authors

Yi Liu¹, Yingting Wu¹, Mengxi Jiang^{1

2}

Affiliations

¹ Department of Pharmacology, School of Basic Medical Sciences, Capital Medical University, Beijing, China.
² Advanced Innovation Center for Human Brain Protection, Capital Medical University, Beijing, China.

Abstract

Emerging evidence suggests that phosphoethanolamine/phosphocholine phosphatase 1 (PHOSPHO1), a specific phosphoethanolamine and phosphocholine phosphatase, is involved in energy metabolism. In this review, we describe the structure and regulation of PHOSPHO1, as well as current knowledge about the role of PHOSPHO1 and its related phospholipid metabolites in regulating energy metabolism. We also examine mechanistic evidence of PHOSPHO1- and phospholipid-mediated regulation of mitochondrial and lipid droplets functions in the context of metabolic homeostasis, which could be potentially targeted for treating metabolic disorders.

Keywords: PHOSPHO1; lipid droplets; metabolic disorders; mitochondrial function; phospholipid homeostasis.

Publication types

Review