An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study

Jamie Afghani; Claudia Traidl-Hoffmann; Philippe Schmitt-Kopplin; Matthias Reiger; Constanze Mueller

doi:10.3390/ijms23158791

An Overview of the Latest Metabolomics Studies on Atopic Eczema with New Directions for Study

Int J Mol Sci. 2022 Aug 8;23(15):8791. doi: 10.3390/ijms23158791.

Authors

Jamie Afghani^{1

2

3

4

5}, Claudia Traidl-Hoffmann^{1

3

4

5}, Philippe Schmitt-Kopplin^{2

3

6}, Matthias Reiger^{1

4

5}, Constanze Mueller^{5

6}

Affiliations

¹ Department of Environmental Medicine, Medical Faculty, University Augsburg, 86156 Augsburg, Germany.
² Chair of Analytical Food Chemistry, School of Life Sciences, Technical University of Munich, 85354 Freising, Germany.
³ ZIEL-Institute for Food and Health, Technical University of Munich, 85354 Freising, Germany.
⁴ Christine Kühne Center for Allergy Research and Education (CK-CARE), 7265 Davos, Switzerland.
⁵ Institute of Environmental Medicine, German Research Center for Environmental Health, Helmholtz Zentrum München, 85764 Neuherberg, Germany.
⁶ Research Unit Analytical BioGeoChemistry, German Research Center for Environmental Health, Helmholtz Zentrum München, 85764 Neuherberg, Germany.

Abstract

Atopic eczema (AE) is an inflammatory skin disorder affecting approximately 20% of children worldwide and early onset can lead to asthma and allergies. Currently, the mechanisms of the disease are not fully understood. Metabolomics, the analysis of small molecules in the skin produced by the host and microbes, opens a window to observe the mechanisms of the disease which then may lead to new drug targets for AE treatment. Here, we review the latest advances in AE metabolomics, highlighting both the lipid and non-lipid molecules, along with reviewing the metabolites currently known to reside in the skin.

Keywords: atopic dermatitis; atopic eczema; dermatitis; lipidomics; metabolomics; skin.

Publication types

Review

MeSH terms

Asthma*
Child
Dermatitis, Atopic* / drug therapy
Eczema*
Humans
Skin

Grants and funding

All research was funded by the Christine Kühne—Center for Allergy Research and Education (CK-CARE) (M.R. and C.T.-H.), and by the Initiative and Networking Fund (Immunology & Inflammation) of the Helmholtz Association (IVF).