lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions

Bohao Zhao; Jiali Li; Ming Liu; Shuaishuai Hu; Naisu Yang; Shuang Liang; Xiyu Zhang; Yingying Dai; Zhiyuan Bao; Yang Chen; Xinsheng Wu

doi:10.3390/cells11152443

lncRNA2919 Suppresses Rabbit Dermal Papilla Cell Proliferation via trans-Regulatory Actions

Cells. 2022 Aug 6;11(15):2443. doi: 10.3390/cells11152443.

Authors

Bohao Zhao¹, Jiali Li¹, Ming Liu¹, Shuaishuai Hu¹, Naisu Yang¹, Shuang Liang¹, Xiyu Zhang¹, Yingying Dai¹, Zhiyuan Bao¹, Yang Chen¹, Xinsheng Wu^{1

2}

Affiliations

¹ College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, China.
² Joint International Research Laboratory of Agriculture & Agri-Product Safety, Yangzhou University, Yangzhou 225009, China.

Abstract

Hair follicles (HFs) are complex organs that grow cyclically during mammals' growth and development. Long non-coding RNAs (lncRNAs) cannot be translated into proteins and play crucial roles in many biological processes. In our previous study, candidate lncRNAs associated with HF cyclic regeneration were screened, and we identified that the novel lncRNA, lncRNA2919, was significantly expressed during catagen. Here, we identified that lncRNA2919 has no coding potentiality and is highly expressed in the cell nucleus, and downregulates HF growth and development-related genes, inhibits cell proliferation, and promotes cell apoptosis in rabbit dermal papilla cells. lncRNA2919 recruits STAT1 to form a compound. As a key transcription factor, STAT1 regulates the transcriptional expression of KRTAP11-1. Our study revealed that lncRNA2919 is involved in HF cyclic regeneration through the trans-regulatory lncRNA2919-STAT1-KRTAP11-1 axis. This study elucidates the mechanism through which lncRNA2919 regulates HF growth and development and the role of lncRNA2919 as a new therapeutic target in animal wool production and human hair-related disease treatment.

Keywords: KRTAP11-1; STAT1; dermal papilla cells; hair follicle growth and development; lncRNA2919; trans regulation.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Cell Proliferation / genetics
Gene Expression Regulation
Hair
Hair Follicle
Humans
Mammals
RNA, Long Noncoding* / genetics
RNA, Long Noncoding* / metabolism
Rabbits

Substances

RNA, Long Noncoding

Grants and funding

This research was funded by the National Natural Science Foundation of China (grant no. 32072724), and the China Agriculture Research System of MOF and MARA (CARS-43-A-1).