Dynamics of the Immune Response in Hospitalized SARS-CoV-2-infected Cancer Patients

Cancer Invest. 2022 Oct;40(9):750-759. doi: 10.1080/07357907.2022.2112693. Epub 2022 Aug 21.

Abstract

Seroconversion rates were compared between oncological and nononcological patients infected with SARS-CoV-2 during a 14-day hospitalization time. All COVID-19 non-oncological and solid malignancies patients reached 100% seroconversion at day 14, while less than half of the hematological patients were seroconverted at the same time point. Despite the limited number and variability of the patient's cohort, we conclude that there is a delayed seroconversion in the hematological malignancies group, which may be linked to changes in the hematological parameters, immune suppression and/or oncological treatments that are typically associated with these patients.

Keywords: COVID-19; IgG antibodies; cancer; immunity; seroconversion.

MeSH terms

  • Antibodies, Viral
  • COVID-19*
  • Humans
  • Immunity
  • Neoplasms*
  • SARS-CoV-2

Substances

  • Antibodies, Viral