Phototheranostics for multifunctional treatment of cancer with fluorescence imaging

Xiaoran Yin; Yifan Cheng; Yan Feng; Wesley R Stiles; Seung Hun Park; Homan Kang; Hak Soo Choi

doi:10.1016/j.addr.2022.114483

Phototheranostics for multifunctional treatment of cancer with fluorescence imaging

Adv Drug Deliv Rev. 2022 Oct:189:114483. doi: 10.1016/j.addr.2022.114483. Epub 2022 Aug 6.

Authors

Xiaoran Yin¹, Yifan Cheng², Yan Feng², Wesley R Stiles³, Seung Hun Park³, Homan Kang⁴, Hak Soo Choi⁵

Affiliations

¹ Department of Oncology, The Second Affiliate Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China; Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
² Department of Oncology, The Second Affiliate Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, China.
³ Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA.
⁴ Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: hkang7@mgh.harvard.edu.
⁵ Gordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA. Electronic address: hchoi12@mgh.harvard.edu.

Abstract

Phototheranostics stem from the recent advances in nanomedicines and bioimaging to diagnose and treat human diseases. Since tumors' diversity, heterogeneity, and instability limit the clinical application of traditional diagnostics and therapeutics, phototheranostics, which combine light-induced therapeutic and diagnostic modalities in a single platform, have been widely investigated. Numerous efforts have been made to develop phototheranostics for efficient light-induced antitumor therapeutics with minimal side effects. Herein, we review the fundamentals of phototheranostic nanomedicines with their biomedical applications. Furthermore, the progress of near-infrared fluorescence imaging and cancer treatments, including photodynamic therapy and photothermal therapy, along with chemotherapy, immunotherapy, and gene therapy, are summarized. This review also discusses the opportunities and challenges associated with the clinical translation of phototheranostics in pan-cancer research. Phototheranostics can pave the way for future research, improve the quality of life, and prolong cancer patients' survival times.

Keywords: Cancer therapy; Fluorescence; Image-guided gene therapy; Multifunctional Nanoparticles; Near-infrared; Photodynamic therapy; Photoimmunotherapy; Phototheranostics; Photothermal therapy.

Publication types

Review
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Humans
Nanoparticles*
Neoplasms* / diagnostic imaging
Neoplasms* / drug therapy
Optical Imaging
Photochemotherapy* / methods
Quality of Life
Theranostic Nanomedicine / methods

Abstract

Publication types

MeSH terms

Grants and funding