MiR-1294 inhibits the progression of breast cancer via regulating ERK signaling

Kejie Chen; Xiapeng Xiao; Zhiping Xu

doi:10.1016/j.bulcan.2022.02.017

MiR-1294 inhibits the progression of breast cancer via regulating ERK signaling

Bull Cancer. 2022 Oct;109(10):999-1006. doi: 10.1016/j.bulcan.2022.02.017. Epub 2022 Aug 6.

Authors

Kejie Chen¹, Xiapeng Xiao¹, Zhiping Xu²

Affiliations

¹ Ningde Municipal Hospital of Ningde Normal University, Department of General Surgery, Ningde, Fujian, People's Republic of China.
² Ningde Municipal Hospital of Ningde Normal University, Department of Oncology Surgery, Ningde, Fujian, People's Republic of China. Electronic address: xuzhiping8102@163.com.

PMID: 35940944
DOI: 10.1016/j.bulcan.2022.02.017

Abstract

Breast cancer (BC) is the most diagnosed carcinoma in women worldwide, which is characterized with a high incidence rate and poor prognosis. MicroRNAs (miRNAs) are promising biomarkers for early detection of BC. In this study, we demonstrated that MiR1294 was downregulated in BC. Moreover, we revealed that MiRNA1294 significantly suppressed cell proliferation, migration and invasion. Animal models revealed that MiRNA1294 reduced tumor formation. In addition, we found that ERK signaling was involved in the regulatory role of MiRNA1294 in BC. In conclusion, MiRNA1294 acted as a tumor suppressor in BC, which might serve as a potential target for the development of anti-neoplastic therapies in BC.

Keywords: Breast cancer (BC); ERK; MiRNA1294.

MeSH terms

Animals
Cell Line, Tumor
Cell Movement / genetics
Cell Proliferation / genetics
Female
Gene Expression Regulation, Neoplastic*
MicroRNAs* / genetics
Neoplasm Invasiveness / genetics

Substances

MicroRNAs