Effects of Acceptance and Commitment Therapy (ACT) and Mindfulness-Based Stress Reduction (MBSR) on symptoms and emotional competencies in individuals with multiple sclerosis

Mult Scler Relat Disord. 2022 Nov:67:104029. doi: 10.1016/j.msard.2022.104029. Epub 2022 Jul 6.

Abstract

Background: Compared to the general population, individuals with multiple sclerosis (MS) report higher levels of insomnia, depression, fatigue, and paresthesia, and lower levels of emotional competencies (understanding emotions in self and others). Available treatments are limited, and novel approaches to reducing symptoms and enhancing emotional competencies in MS are needed. Two potentially beneficial treatments are Acceptance and Commitment Therapy (ACT) and Mindfulness-Based Stress Reduction (MBSR). The aim of the present study was to investigate the impact of ACT and MBSR on symptoms and emotional competencies in patients with MS.

Methods: A total of 76 individuals with MS (81.6% females; mean age: 38.88 years; EDSS median: 2; range: 0-5) were randomly assigned to an 8-week ACT treatment, an 8-week MBSR treatment, or a wait-list control condition. At baseline and study-end (week 8), participants completed a series of questionnaires covering symptoms and emotional competencies. At mid-term (week 4), participants rated their insomnia and depression.

Results: Over time, symptoms of MS decreased (medium effect size for insomnia, fatigue, and paresthesia, and large effect size for depression) and emotional competencies improved (large effect size), but more so in the MBSR and ACT conditions, compared with the control condition. At study-end, the outcome improvement did not differ between the ACT and MBSR conditions.

Conclusions: Both ACT and MBSR led to reduced symptoms and enhanced emotional competencies. Psychotherapeutic interventions such as these should be considered as a means of decreasing symptoms and increasing emotional competencies among individuals with MS.

Keywords: Acceptance and Commitment Therapy (ACT); Depression; Emotional competencies; Fatigue; Insomnia; Mindfulness-Based Stress Reduction (MBSR); Multiple sclerosis; Paresthesia.

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Acceptance and Commitment Therapy*
  • Adult
  • Anxiety / psychology
  • Depression / psychology
  • Depression / therapy
  • Emotions
  • Fatigue / etiology
  • Fatigue / psychology
  • Fatigue / therapy
  • Female
  • Humans
  • Male
  • Mindfulness*
  • Multiple Sclerosis* / complications
  • Multiple Sclerosis* / therapy
  • Paresthesia
  • Sleep Initiation and Maintenance Disorders* / etiology
  • Sleep Initiation and Maintenance Disorders* / therapy
  • Stress, Psychological / psychology
  • Stress, Psychological / therapy
  • Treatment Outcome