Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets

Yuqi Zhou; Masako Nishikawa; Hiroshi Kanno; Ruoxi Yang; Yuma Ibayashi; Ting-Hui Xiao; Walker Peterson; Maik Herbig; Nao Nitta; Shigeki Miyata; Yogendra Kanthi; Gustavo K Rohde; Kyoji Moriya; Yutaka Yatomi; Keisuke Goda

doi:10.1002/cyto.a.24677

Long-term effects of Pfizer-BioNTech COVID-19 vaccinations on platelets

Cytometry A. 2023 Feb;103(2):162-167. doi: 10.1002/cyto.a.24677. Epub 2022 Aug 8.

Authors

Yuqi Zhou¹, Masako Nishikawa², Hiroshi Kanno¹, Ruoxi Yang¹, Yuma Ibayashi¹, Ting-Hui Xiao¹, Walker Peterson¹, Maik Herbig¹, Nao Nitta³, Shigeki Miyata⁴, Yogendra Kanthi⁵, Gustavo K Rohde^{6

7}, Kyoji Moriya^{8

9}, Yutaka Yatomi^{2

10}, Keisuke Goda^{1

3

11

12}

Affiliations

¹ Department of Chemistry, The University of Tokyo, Tokyo, Japan.
² Department of Clinical Laboratory, The University of Tokyo Hospital, Tokyo, Japan.
³ CYBO, Inc, Tokyo, Japan.
⁴ Research and Development Department, Central Blood Institute, Japanese Red Cross Society, Tokyo, Japan.
⁵ National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA.
⁶ Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA.
⁷ Department of Electrical and Computer Engineering, University of Virginia, Charlottesville, Virginia, USA.
⁸ Department of Infection Control and Prevention, The University of Tokyo Hospital, Tokyo, Japan.
⁹ Department of Infectious Diseases, The University of Tokyo Hospital, Tokyo, Japan.
¹⁰ Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
¹¹ Institute of Technological Sciences, Wuhan University, Wuhan, China.
¹² Department of Bioengineering, University of California, Los Angeles, California, USA.

Abstract

There is a global concern about the safety of COVID-19 vaccines associated with platelet function. However, their long-term effects on overall platelet activity remain poorly understood. Here we address this problem by image-based single-cell profiling and temporal monitoring of circulating platelet aggregates in the blood of healthy human subjects, before and after they received multiple Pfizer-BioNTech (BNT162b2) vaccine doses over a time span of nearly 1 year. Results show no significant or persisting platelet aggregation trends following the vaccine doses, indicating that any effects of vaccinations on platelet turnover, platelet activation, platelet aggregation, and platelet-leukocyte interaction was insignificant.

Keywords: COVID-19; mRNA vaccine; platelet aggregation; thrombosis.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, N.I.H., Intramural

MeSH terms

BNT162 Vaccine
Blood Platelets
COVID-19 Vaccines* / adverse effects
COVID-19* / prevention & control
Humans
Vaccination / adverse effects

Substances

COVID-19 Vaccines
BNT162 Vaccine

Abstract

Publication types

MeSH terms

Substances

Grants and funding