Knowledge Domains and Emerging Trends of Osteoblasts-Osteoclasts in Bone Disease From 2002 to 2021: A Bibliometrics Analysis and Visualization Study

Jun Hou; Hongjie Su; Xiaocong Kuang; Wencong Qin; Kaibing Liu; Kaixiang Pan; Bokai Zhang; Sijie Yang; Shenghui Yang; Xiao Peng; Xinyu Nie; Qikai Hua

doi:10.3389/fendo.2022.922070

Knowledge Domains and Emerging Trends of Osteoblasts-Osteoclasts in Bone Disease From 2002 to 2021: A Bibliometrics Analysis and Visualization Study

Front Endocrinol (Lausanne). 2022 Jul 22:13:922070. doi: 10.3389/fendo.2022.922070. eCollection 2022.

Authors

Jun Hou^{1

2}, Hongjie Su^{1

2}, Xiaocong Kuang^{1

2}, Wencong Qin^{1

2}, Kaibing Liu^{1

2}, Kaixiang Pan^{1

2}, Bokai Zhang^{1

2}, Sijie Yang^{1

2}, Shenghui Yang^{1

2}, Xiao Peng^{1

2}, Xinyu Nie³, Qikai Hua^{1

2}

Affiliations

¹ Department of Bone and Joint Surgery, Research Centre for Regenerative Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
² Guangxi Diabetic Foot Salvage Engineering Research Center, Guangxi Medical University, Nanning, China.
³ Department of Orthopaedics, The Second Hospital, Jilin University, Changchun, China.

Abstract

Background: Osteoblasts-Osteoclasts has been a major area in bone disease research for a long time. However, there are few systematic studies in this field using bibliometric analysis. We aimed to perform a bibliometric analysis and visualization study to determine hotspots and trends of osteoblasts-osteoclasts in bone diseases, identify collaboration and influence among authors, countries, institutions, and journals, and assess the knowledge base to develop basic and clinical research in the future.

Methods: We collected articles and reviews for osteoblasts-osteoclasts in bone diseases from the Web of Science Core Collection. In addition, we utilized scientometrics software (CiteSpace5.8 and VOSviewer1.6.18) for visual analysis of countries/regions, institutions, authors, references, and keywords in the field.

Results: In total, 16,832 authors from 579 institutions in 73 countries/regions have published 3,490 papers in 928 academic journals. The literature in this field is rapidly increasing, with Bone publishing the most articles, whereas Journal of Bone and Mineral Research had the most co-cited journals. These two journals mainly focused on molecular biology and the clinical medicine domain. The countries with the highest number of publications were the US and China, and the University of Arkansas for Medical Sciences was the most active institution. Regarding authors, Stavros C. Manolagas published the most articles, and Hiroshi Takayanagi had the most co-cited papers. Research in this field mainly includes molecular expression and regulatory mechanisms, differentiation, osteoprotection, inflammation, and tumors. The latest research hotspots are oxidative stress, mutation, osteocyte formation and absorption, bone metabolism, tumor therapy, and in-depth mechanisms.

Conclusion: We identified the research hotspots and development process of osteoblasts-osteoclasts in bone disease using bibliometric and visual methods. Osteoblasts-osteoclasts have attracted increasing attention in bone disease. This study will provide a valuable reference for researchers concerned with osteoblasts-osteoclasts in bone diseases.

Keywords: bibliometrics; bone diseases; citespace; osteoblasts; osteoclasts; vosviewer.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Bibliometrics
Bone Diseases*
Humans
Osteoblasts
Osteoclasts*
Publications