Quantitative Analysis of Vertical Transmission of Maternal SARS-CoV-2 Antibodies to Neonates and Young Infants Following Immunization During Pregnancy

Naama Golan; Shai Ashkenazi; Rotem Davidovich; Alina Levinsky; Adina Bar Chaim; Ramzia Abu Hamad; Omer Raveh; Shai Yitzhaki; Gilat Livni

doi:10.1093/jpids/piac065

Quantitative Analysis of Vertical Transmission of Maternal SARS-CoV-2 Antibodies to Neonates and Young Infants Following Immunization During Pregnancy

J Pediatric Infect Dis Soc. 2022 Dec 5;11(11):506-509. doi: 10.1093/jpids/piac065.

Authors

Naama Golan¹, Shai Ashkenazi², Rotem Davidovich¹, Alina Levinsky¹, Adina Bar Chaim³, Ramzia Abu Hamad³, Omer Raveh⁴, Shai Yitzhaki¹, Gilat Livni^{1

5}

Affiliations

¹ Department of Pediatrics A, Schneider Children's Medical Center, Petah Tikva, Israel.
² Adelson School of Medicine, Ariel University, Ariel, Israel.
³ Laboratory of Clinical Chemistry, Shamir Medical Center, Beer Yaakov, Israel.
⁴ Department of Emergency Pediatrics, Schneider Children's Medical Center, Petah Tikva, Israel.
⁵ Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.

Abstract

Serum antibody levels to SARS-CoV-2 in infants born to mothers who had received 2 doses of the BNT2b2 vaccine during pregnancy correlated positively with increasing gestational age at vaccination (P < .01) and negatively with increasing time from vaccination (P < .01), with a significant drop in infants aged >60 days (P = .045).

Keywords: COVID-19; infancy; neonates; pregnancy; vaccination.

© The Author(s) 2022. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

MeSH terms

COVID-19* / prevention & control
Female
Humans
Infant
Infant, Newborn
Infectious Disease Transmission, Vertical / prevention & control
Pregnancy
Pregnancy Complications, Infectious* / prevention & control
SARS-CoV-2
Vaccination