One new limonoid with cytotoxicity against glioma cell lines from Cipadessa baccifera

Zhao Kun; Li Lin; Zheng Xiang

doi:10.1080/14786419.2022.2106482

One new limonoid with cytotoxicity against glioma cell lines from Cipadessa baccifera

Nat Prod Res. 2024 Jan-Feb;38(1):152-157. doi: 10.1080/14786419.2022.2106482. Epub 2022 Aug 3.

Authors

Zhao Kun¹, Li Lin², Zheng Xiang³

Affiliations

¹ Department of Minimally Invasive Treatment Center, The Fourth Affiliated Hospital of China Medical University, Shenyang, China.
² The First Oncology Department, The Fourth Hospital of China Medical University, Shenyang, China.
³ School of Pharmaceutical Science, Liaoning University, Shenyang, China.

PMID: 35921334
DOI: 10.1080/14786419.2022.2106482

Abstract

Glioma is a common malignant tumor with a high incidence rate but a low cure rate. In this paper, one previously undescribed limonoid (1), along with two known cipadesin-type limonoids 2 and 3, were isolated from Cipadessa baccifera. Their structures were established based on a comprehensive analysis of NMR and MS spectra. Compound 1 exhibited moderate cytotoxicity against U251 and BT-325 cells with IC₅₀ values of 7.32 ± 0.21 and 13.25 ± 0.35 μM, suggesting that 1 might be a promising leading compound for the treatment of glioma.

Keywords: Cipadessa baccifera (Roth) Miq.; U251; cytotoxicity.

MeSH terms

Cell Line, Tumor
Glioma* / drug therapy
Humans
Limonins* / chemistry
Limonins* / pharmacology
Magnetic Resonance Spectroscopy
Meliaceae* / chemistry
Molecular Structure

Substances

Limonins