Effect of natural products use prior to infection with COVID-19 on disease severity and hospitalization: A self-reported cross-sectional survey study

F1000Res. 2022 Jun 10:11:639. doi: 10.12688/f1000research.121933.2. eCollection 2022.

Abstract

Background: Managing coronavirus disease 2019 (COVID-19) using available resources is essential to reduce the health burden of disease. The severity of COVID-19 is affected by nutritional status. In this study the effect of natural product use prior to infection with COVID-19 on disease severity and hospitalization was explored. Methods: This was a cross-sectional study. Between March and July 2021, a self-administered survey was conducted in Jordan. Individuals who recovered from COVID-19 and were ≥18 years old were the study population. Study measures included the use of natural products, COVID-19 severity, and hospitalization status. A multivariate regression model was used for statistical analysis. Results: The mean age (mean ± SD) of the study sample (n=2,148) was 40.25 ± 15.58 years old. Multivariate logistic regression showed that the regular intake of carnation (OR [0.56], CI [0.37-0.85]), onion (OR [0.69], CI [0.52-0.92]), lemon (OR [0.68], CI [0.51-0.90]), and citrus fruits (OR [0.66], CI [0.50-0.89]) before infection were associated with a substantial reduction in COVID-19 severity (P<0.01). Also, the consumption of carnation (OR [0.55], CI [0.34-0.88]), lemon (OR [0.57], CI [0.42-0.78]), and citrus fruits (OR [0.61], CI [0.44-0.84]) were associated with a significant decrease in the frequency of COVID-19-induced hospitalization (P<0.01). Conclusions: Regular consumption of carnation, lemon, and citrus fruits before infection was associated with better outcomes for COVID-19. Studies on other populations are required to confirm these findings.

Keywords: COVID-19; carnation; citrus; hospitalization; lemon; natural products; onion; severity.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Products* / therapeutic use
  • COVID-19*
  • Cross-Sectional Studies
  • Hospitalization
  • Humans
  • SARS-CoV-2
  • Self Report
  • Severity of Illness Index

Substances

  • Biological Products

Associated data

  • figshare/10.6084/m9.figshare.19758820

Grants and funding

This work was supported by the Deanship of Research, Jordan University of Science and Technology (Grant number 20210173; to Dr. Refat Nimer).