Inflammation as a link between periodontal disease and obesity

Periodontol 2000. 2022 Oct;90(1):186-196. doi: 10.1111/prd.12457. Epub 2022 Aug 2.

Abstract

Nutrition plays a critical role in the homeostatic balance, maintenance of health, and longevity. There is a close link between inflammatory diseases and nutritional health. Obesity is a severe pathological process with grave implications on several organ systems and disease processes, including type 2 diabetes, cardiovascular disease, osteoarthritis, and rheumatoid arthritis. The impact of obesity on periodontal inflammation has not been fully understood; the association between nutritional balance and periodontal inflammation is much less explored. This review is focused on the potential mechanistic links between periodontal diseases and obesity and common inflammatory activity pathways that can be pharmacologically targeted.

Keywords: inflammation; nutrition; obesity; periodontal disease.

Publication types

  • Review
  • Research Support, N.I.H., Extramural

MeSH terms

  • Cardiovascular Diseases*
  • Diabetes Mellitus, Type 2* / complications
  • Humans
  • Inflammation / complications
  • Obesity / complications
  • Periodontal Diseases* / complications