A "3S+f" Nephrometry Score System to Predict the Clinical Outcomes of Laparoscopic Nephron-Sparing Surgery

Shudong Zhang; Zijian Qin; Hai Bi; Liyuan Tao; Fan Zhang; Hongxian Zhang; Wei Wang; Jitao Wu; Yi Huang; Lulin Ma

doi:10.3389/fonc.2022.922082

A "3S+f" Nephrometry Score System to Predict the Clinical Outcomes of Laparoscopic Nephron-Sparing Surgery

Front Oncol. 2022 Jul 14:12:922082. doi: 10.3389/fonc.2022.922082. eCollection 2022.

Authors

Shudong Zhang¹, Zijian Qin¹, Hai Bi¹, Liyuan Tao², Fan Zhang¹, Hongxian Zhang¹, Wei Wang³, Jitao Wu⁴, Yi Huang¹, Lulin Ma¹

Affiliations

¹ Department of Urology, Peking University Third Hospital, Peking University, Beijing, China.
² Department of Epidemiology, Peking University Third Hospital, Peking University, Beijing, China.
³ Department of Urology, Peking Tongren Hospital, Beijing, China.
⁴ Department of Urology, Yantai Yuhuangding Hospital, Yantai, China.

Abstract

Background: When we treat renal cell carcinoma by laparoscopic nephron-sparing surgery (NSS), it is essential to use an evaluation system to predict clinical outcomes. Hitherto, there are more than a dozen nephrometry score systems. In this study, through assessing the correlations between nephrometry score systems and clinical outcomes, we aim to provide a novel nephrometry score system-the "3S+f" score system-to simplify the evaluation of technical complexity of partial nephrectomy.

Methods: We retrospectively collected the data of 131 patients who underwent NSS, which was performed by a single surgeon (SZ) from January 2013 to July 2018 at Peking University Third Hospital. The "3S+f" score system contains four parameters: "size, side, site, and fat", all of which can be obtained from preoperative imaging data. We evaluated the correlations between the "3S+f" score and clinical outcomes, and compared R.E.N.A.L. score and PADUA score.

Results: All the three nephrometry score systems were related to some clinical outcomes in univariate analyses. In multivariate regression models, the "3S+f" score, the R.E.N.A.L. score, and the PADUA score were significantly associated with operative time (p = 0.016, p = 0.035, and p = 0.001, respectively) and warm ischemia time (all p = 0.008, p < 0.001, and p < 0.001, respectively). "3S+f" was also significantly related to extubation time > 5 days (p = 0.018). In predicting operative time > 120 min and extubation time >5 days from ROC curves, the AUCs of the "3S+f" score (0.717 and 0.652, respectively) were larger than both the R.E.N.A.L (0.598 and 0.554, respectively) and PADUA (0.600 and 0.542, respectively) score systems.

Conclusion: A novel nephrometry score system-the "3S+f" score system-shows equivalent correlation and the ability in predicting clinical outcomes when compared to the R.E.N.A.L. score system and the PADUA score system, which can describe renal tumors.

Keywords: laparoscopy; nephrometry score system; nephron-sparing surgery; renal tumor; “3S+f” nephrometry score system.