Aberrant branched-chain amino acid catabolism in cardiovascular diseases

Yixiao Xiong; Ling Jiang; Tao Li

doi:10.3389/fcvm.2022.965899

Aberrant branched-chain amino acid catabolism in cardiovascular diseases

Front Cardiovasc Med. 2022 Jul 15:9:965899. doi: 10.3389/fcvm.2022.965899. eCollection 2022.

Authors

Yixiao Xiong^{1

2}, Ling Jiang^{1

2}, Tao Li^{1

2}

Affiliations

¹ Department of Anesthesiology, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China.
² Laboratory of Mitochondria and Metabolism, West China Hospital of Sichuan University, Chengdu, China.

Abstract

Globally, cardiovascular diseases are the leading cause of death. Research has focused on the metabolism of carbohydrates, fatty acids, and amino acids to improve the prognosis of cardiovascular diseases. There are three types of branched-chain amino acids (BCAAs; valine, leucine, and isoleucine) required for protein homeostasis, energy balance, and signaling pathways. Increasing evidence has implicated BCAAs in the pathogenesis of multiple cardiovascular diseases. This review summarizes the biological origin, signal transduction pathways and function of BCAAs as well as their significance in cardiovascular diseases, including myocardial hypertrophy, heart failure, coronary artery disease, diabetic cardiomyopathy, dilated cardiomyopathy, arrhythmia and hypertension.

Keywords: branched-chain amino acids; cardiovascular diseases; catabolism; coronary artery disease; heart failure.

Publication types

Review