Synthesis of Bioactive Yttrium-Metal-Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Raed Obaid Saleh; Harun Achmad; Botir Turgunpulatovich Daminov; Hamzah H Kzar; Ahmed B Mahdi; Ali Thaeer Hammid; Mohammed Kadhem Abid; Maria Jade Catalan Opulencia; Yasser Fakri Mustafa; Himanshu Sharma

doi:10.3389/fchem.2022.928047

Synthesis of Bioactive Yttrium-Metal-Organic Framework as Efficient Nanocatalyst in Synthesis of Novel Pyrazolopyranopyrimidine Derivatives and Evaluation of Anticancer Activity

Front Chem. 2022 Jul 14:10:928047. doi: 10.3389/fchem.2022.928047. eCollection 2022.

Affiliations

¹ Department of Pharmacy, Al-Maarif University College, Al-Anbar, Iraq.
² Department of Pediatric Dentistry, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia.
³ Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan.
⁴ Veterinary Medicine College, Al-Qasim Green University, Al-Qasim, Iraq.
⁵ Anesthesia Techniques Department, Al-Mustaqbal University College, Babylon, Iraq.
⁶ Computer Engineering Techniques Department, Faculty of Information Technology, Imam Ja'afar Al-Sadiq University, Baghdad, Iraq.
⁷ Department of Anesthesia, College of Health and Medical Technology, Al-Ayen University, Thi-Qar, Iraq.
⁸ College of Business Administration, Ajman University, Ajman, United Arab Emirates.
⁹ Department of Pharmaceutical Chemistry, College of Pharmacy, University of Mosul, Mosul, Iraq.
¹⁰ Department of Computer Engineering and Applications, GLA University, Mathura, India.

Abstract

Novel Yttrium-metal-organic framework (Y-MOF) was synthesized under optimal conditions of microwave with a power of 20 W, the temperature of 30 degrees of centigrade, and time duration of 10 min. The products were characterized by SEM (morphology and size distribution), TGA (thermal stability), BET technique (surface area), and FTIR (characterization of the related group). The Yttrium-metal-organic framework (Y-MOF) synthesized in this study, after identifying and confirming the structure, was used as an efficient and recyclable catalyst in the synthesis of new pyrazolopyranopyrimidine derivatives. Following the study of the properties and applications of Y-MOF, its anticancer properties on breast cancer cells based on the MTT method were evaluated, and significant results were observed. In addition, the anticancer properties of the pyrazolopyranopyrimidine derivatives were investigated.

Keywords: MTT method; Y-MOF; anticancer activity; breast cancer cells; pyrazolopyranopyrimidines.

Publication types

Retracted Publication