Metabolic and cellular engineering for the production of natural products

Dongsoo Yang; Hyunmin Eun; Cindy Pricilia Surya Prabowo; Sumin Cho; Sang Yup Lee

doi:10.1016/j.copbio.2022.102760

Metabolic and cellular engineering for the production of natural products

Curr Opin Biotechnol. 2022 Oct:77:102760. doi: 10.1016/j.copbio.2022.102760. Epub 2022 Jul 28.

Authors

Dongsoo Yang¹, Hyunmin Eun², Cindy Pricilia Surya Prabowo², Sumin Cho², Sang Yup Lee³

Affiliations

¹ Metabolic and Biomolecular Engineering National Research Laboratory and Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Institute for the BioCentury and KAIST Institute for Artificial Intelligence, KAIST, Daejeon 34141, Republic of Korea; BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, Daejeon 34141, Republic of Korea. Electronic address: dosoyang@kaist.ac.kr.
² Metabolic and Biomolecular Engineering National Research Laboratory and Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Institute for the BioCentury and KAIST Institute for Artificial Intelligence, KAIST, Daejeon 34141, Republic of Korea.
³ Metabolic and Biomolecular Engineering National Research Laboratory and Systems Metabolic Engineering and Systems Healthcare Cross-Generation Collaborative Laboratory, Department of Chemical and Biomolecular Engineering (BK21 four), Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, Republic of Korea; KAIST Institute for the BioCentury and KAIST Institute for Artificial Intelligence, KAIST, Daejeon 34141, Republic of Korea; BioProcess Engineering Research Center and BioInformatics Research Center, KAIST, Daejeon 34141, Republic of Korea. Electronic address: leesy@kaist.ac.kr.

PMID: 35908315
DOI: 10.1016/j.copbio.2022.102760

Abstract

Increased awareness of the environmental and health concerns of consuming chemically synthesized products has led to a rising demand for natural products that are greener and more sustainable. Despite their importance, however, industrial-scale production of natural products has been challenging due to the low yield and high cost of the bioprocesses. To cope with this problem, systems metabolic engineering has been employed to efficiently produce natural products from renewable biomass. Here, we review the recent systems metabolic engineering strategies employed for enhanced production of value-added natural products, together with accompanying examples. Particular focus is set on systems-level engineering and cell physiology engineering strategies. Future perspectives are also discussed.

Publication types

Review
Research Support, Non-U.S. Gov't

MeSH terms

Biological Products*
Biomass
Fermentation
Metabolic Engineering

Substances

Biological Products