Association between TGF-β gene polymorphism and myopia: A systematic review and meta-analysis

Medicine (Baltimore). 2022 Jul 29;101(30):e29961. doi: 10.1097/MD.0000000000029961.

Abstract

Introduction: The present study was conducted to determine the association of transforming growth factor-beta (TGF-β) gene polymorphism and myopia.

Method: Four hundred twelve articles were identified, of which 11 articles with 5213 participants in 4 countries were included in the final analysis. Review Manager software (RevMan, version 5.4) was used for data analysis.

Result: Odds ratio (OR) value of TGF-β1 rs1800469 is 1.33 (95% confidence interval [CI] = 1.15-1.54) in the allelic model; in the dominant model is 1.76 (95% CI = 1.16-2.67); in homozygous model is 5.98 (95% CI = 4.31-8.06). OR value of TGF-β1 rs4803455 is 0.62 (95% CI = 0.43-0.88) in recessive model. TGF-β2 is not associated with myopia. Relevant study on TGF-β3 is scarce.

Conclusion: Our systematic review and meta-analysis found that TGF-β1 rs4803455 and rs1800469 were correlated with myopia.

Publication types

  • Meta-Analysis
  • Systematic Review

MeSH terms

  • Alleles
  • Genetic Predisposition to Disease
  • Humans
  • Myopia* / genetics
  • Polymorphism, Genetic
  • Polymorphism, Single Nucleotide
  • Transforming Growth Factor beta1 / genetics
  • Transforming Growth Factor beta1 / therapeutic use*

Substances

  • TGFB1 protein, human
  • Transforming Growth Factor beta1