Resting-State Brain Temperature: Dynamic Fluctuations in Brain Temperature and the Brain-Body Temperature Gradient

Dongsuk Sung; Benjamin B Risk; Kelly J Wang; Jason W Allen; Candace C Fleischer

doi:10.1002/jmri.28376

Resting-State Brain Temperature: Dynamic Fluctuations in Brain Temperature and the Brain-Body Temperature Gradient

J Magn Reson Imaging. 2023 Apr;57(4):1222-1228. doi: 10.1002/jmri.28376. Epub 2022 Jul 29.

Authors

Dongsuk Sung^{1

2}, Benjamin B Risk³, Kelly J Wang^{1

4}, Jason W Allen^{1

2}, Candace C Fleischer^{1

2}

Affiliations

¹ Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
² Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, USA.
³ Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia, USA.
⁴ Department of Neuroscience, Georgia Institute of Technology, Atlanta, Georgia, USA.

Abstract

Background: While fluctuations in healthy brain temperature have been investigated over time periods of weeks to months, dynamics over shorter time periods are less clear.

Purpose: To identify physiological fluctuations in brain temperature in healthy volunteers over time scales of approximately 1 hour.

Study type: Prospective.

Subjects: A total of 30 healthy volunteers (15 female; 26 ± 4 years old).

Sequence and field strength: 3 T; T1-weighted magnetization-prepared rapid gradient-echo (MPRAGE) and semi-localized by adiabatic selective refocusing (sLASER) single-voxel spectroscopy.

Assessments: Brain temperature was calculated from the chemical shift difference between N-acetylaspartate and water. To evaluate within-scan repeatability of brain temperature and the brain-body temperature difference, 128 spectral transients were divided into two sets of 64-spectra. Between-scan repeatability was evaluated using two time periods, ~1-1.5 hours apart.

Statistical tests: A hierarchical linear mixed model was used to calculate within-scan and between-scan correlations (R_w and R_b , respectively). Significance was determined at P ≤ .05. Values are reported as the mean ± standard deviation.

Results: A significant difference in brain temperature was observed between scans (-0.4 °C) but body temperature was stable (P = .59). Brain temperature (37.9 ± 0.7 °C) was higher than body temperature (36.5 ± 0.5 °C) for all but one subject. Within-scan correlation was high for brain temperature (R_w = 0.95) and brain-body temperature differences (R_w = 0.96). Between scans, variability was high for both brain temperature (R_b = 0.30) and brain-body temperature differences (R_b = 0.41).

Data conclusion: Significant changes in brain temperature over time scales of ~1 hour were observed. High short-term repeatability suggests temperature changes appear to be due to physiology rather than measurement error.

Evidence level: 2 TECHNICAL EFFICACY: Stage 1.

Keywords: MR thermometry; brain-body temperature differences; healthy brain temperature; resting-state brain temperature.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

MeSH terms

Adult
Body Temperature* / physiology
Brain / physiology
Female
Humans
Magnetic Resonance Imaging* / methods
Prospective Studies
Temperature
Young Adult

Abstract

Publication types

MeSH terms

Grants and funding