"Fateful" encounter: Lineage tracing meets phylogeny to unravel mysteries of cancer progression

Wing Hing Wong; Christina Curtis

doi:10.1016/j.devcel.2022.07.002

"Fateful" encounter: Lineage tracing meets phylogeny to unravel mysteries of cancer progression

Dev Cell. 2022 Jul 25;57(14):1680-1682. doi: 10.1016/j.devcel.2022.07.002.

Authors

Wing Hing Wong¹, Christina Curtis²

Affiliations

¹ Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA.
² Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA; Department of Genetics, Stanford University School of Medicine, Stanford, CA, USA; Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA, USA. Electronic address: cncurtis@stanford.edu.

PMID: 35901781
DOI: 10.1016/j.devcel.2022.07.002

Abstract

In a recent issue of Cell, Yang et al. utilize evolvable cellular barcodes to investigate the evolutionary trajectories of murine lung adenocarcinoma. Reconstructing the life histories of these tumors based on cellular barcodes reveals stringent selection and phenotypic differences across subclonal lineages.

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MeSH terms

Animals
Biological Evolution
Cell Lineage / genetics
Humans
Mice
Neoplasms* / genetics
Phylogeny