Humoral and cellular immune response levels at a 1-year follow-up after mild COVID-19

J Clin Virol. 2022 Sep:154:105236. doi: 10.1016/j.jcv.2022.105236. Epub 2022 Jul 8.

Abstract

The primary objective of this study was to establish a 1-year follow-up of patients after mild COVID-19 with no or only short-term detection of antibodies shortly after disease. At 1 year after disease, cellular memory against SARS-CoV-2, as measured by IFN-γ release by T cells, was detected in 76% (38/50) of participants. The data suggest that even if antibody levels decline after the primary infection has resolved, a cellular immune response may be detectable for longer.

Keywords: Mild COVID-19; SARS-CoV-2; T-cell immune response.

MeSH terms

  • Antibodies, Viral
  • COVID-19*
  • Follow-Up Studies
  • Humans
  • Immunity, Cellular
  • Immunity, Humoral
  • SARS-CoV-2

Substances

  • Antibodies, Viral