What Are the Minimal Feeds Required for Starting Enteral Ibuprofen in Preterm Infants with PDA?

Aimann Surak; Abbas Hyderi

doi:10.3390/pediatric14030040

What Are the Minimal Feeds Required for Starting Enteral Ibuprofen in Preterm Infants with PDA?

Pediatr Rep. 2022 Jul 24;14(3):333-337. doi: 10.3390/pediatric14030040.

Authors

Aimann Surak¹, Abbas Hyderi¹

Affiliation

¹ Northern Alberta Neonatal Program, Philip C. Etches NICU, Royal Alexandra Hospital Site, DTC 5027, 10240 Kingsway NW, Edmonton, AB T5H 3V9, Canada.

Abstract

Ibuprofen is commonly used for the treatment of hemodynamically significant patent ductus arteriosus (PDA) in preterm infants. It seems that the oral formulation incurs a higher closure rate and has a better safety profile in preterm infants born > 26 weeks’ gestation. There is no consensus across Canadian centers regarding the minimum volume of enteral feeds required prior to starting ibuprofen for the treatment of patent ductus arteriosus, and the current practice is comfort-based depending on the centre and the local prevalence of neonatal morbidities.

Keywords: PDA; ibuprofen; preterm.

Grants and funding

No funding was needed neither obtained. No financial interest to declare. No financial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.