Polyphenol Mechanisms against Gastric Cancer and Their Interactions with Gut Microbiota: A Review

Curr Oncol. 2022 Jul 25;29(8):5247-5261. doi: 10.3390/curroncol29080417.

Abstract

The lack of new drugs and resistance to existing drugs are serious problems in gastric cancer(GC) treatment. The research found polyphenols possess anti-Helicobacter pylori(Hp) and antitumor activities and may be used in the research and development of drugs for cancer prevention and treatment. However, polyphenols are affected by their chemical structures and physical properties, which leads to relatively low bioavailability and bioactivity in vivo. The intestinal flora can improve the absorption, utilization, and biological activity of polyphenols, whereas polyphenol compounds can increase the richness of the intestinal flora, reduce the activity of carcinogenic bacteria, stabilize the proportion of core flora, and maintain homeostasis of the intestinal microenvironment. Our review summarizes the gastrointestinal flora-mediated mechanisms of polyphenol against GC.

Keywords: gastric cancer; interaction; intestinal flora; mechanism; polyphenols.

Publication types

  • Review
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biological Availability
  • Gastrointestinal Microbiome*
  • Humans
  • Polyphenols / pharmacology
  • Polyphenols / therapeutic use
  • Stomach Neoplasms* / drug therapy
  • Tumor Microenvironment

Substances

  • Polyphenols

Grants and funding

Several foundations supported our work: the National Natural Science Foundation of China (the funder: Yongning Zhou No. 71964021), the National Key R&D Program of China (the funder: Yuping Wang No. 2016YFC1302201) and the Foundation of The First Hospital of Lanzhou University, China (the funder: Ya Zheng No. ldyyyn2021-59).