Deep brain stimulation for Parkinson's Disease: A Review and Future Outlook

Anahita Malvea; Farbod Babaei; Chadwick Boulay; Adam Sachs; Jeongwon Park

doi:10.1007/s13534-022-00226-y

Deep brain stimulation for Parkinson's Disease: A Review and Future Outlook

Biomed Eng Lett. 2022 Apr 19;12(3):303-316. doi: 10.1007/s13534-022-00226-y. eCollection 2022 Aug.

Authors

Anahita Malvea¹, Farbod Babaei², Chadwick Boulay^{3

4}, Adam Sachs^{3

4

5}, Jeongwon Park^{2

6}

Affiliations

¹ Faculty of Medicine, University of Ottawa, K1H 8M5 Ottawa, ON Canada.
² School of Electrical Engineering and Computer Science, University of Ottawa, K1N 6N5 Ottawa, ON Canada.
³ The Ottawa Hospital Research Institute, Ottawa, Ontario Canada.
⁴ The University of Ottawa Brain and Mind Research Institute, Ottawa, Ontario Canada.
⁵ Division of Neurosurgery, Department of Surgery, The Ottawa Hospital, Ottawa, Ontario Canada.
⁶ Department of Electrical and Biomedical Engineering, University of Nevada, 89557 Reno, NV USA.

Abstract

Parkinson's Disease (PD) is a neurodegenerative disorder that manifests as an impairment of motor and non-motor abilities due to a loss of dopamine input to deep brain structures. While there is presently no cure for PD, a variety of pharmacological and surgical therapeutic interventions have been developed to manage PD symptoms. This review explores the past, present and future outlooks of PD treatment, with particular attention paid to deep brain stimulation (DBS), the surgical procedure to deliver DBS, and its limitations. Finally, our group's efforts with respect to brain mapping for DBS targeting will be discussed.

Keywords: Alzheimer’s; Bradykinesia; Deep brain stimulation (DBS); Dystonia; Essential tremor; Parkinson’s disease (PD); Parkinson’s symptoms; Subthalamic nucleus (STN); Thalamus (VM); Tourette syndrome (TS); Treatment resistant depression (TRD); globus pallidus interna (GPi).

Publication types

Review