Bioavailability of Tauropine After Oral Ingestion in Mouse

Takashi Ito; Khanh Hoang Nguyen; Chitose Maruyama; Yoshimitsu Hamano; Shigeru Murakami; Stephen W Schaffer

doi:10.1007/978-3-030-93337-1_13

Bioavailability of Tauropine After Oral Ingestion in Mouse

Adv Exp Med Biol. 2022:1370:137-142. doi: 10.1007/978-3-030-93337-1_13.

Authors

Takashi Ito¹, Khanh Hoang Nguyen², Chitose Maruyama², Yoshimitsu Hamano², Shigeru Murakami², Stephen W Schaffer³

Affiliations

¹ Faculty of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, Japan. tito@fpu.ac.jp.
² Faculty of Bioscience and Biotechnology, Fukui Prefectural University, Fukui, Japan.
³ Department of Pharmacology, University of South Alabama College of Medicine, Mobile, AL, USA.

PMID: 35882789
DOI: 10.1007/978-3-030-93337-1_13

Abstract

In the present study, we investigated the pharmacokinetics of oral ingested tauropine which is a natural taurine derivative found in marine invertebrates, such as abalone, and in mouse. To measure tauropine in the blood, it was derivatized with phenyl isothiocyanate (PITC), and PITC-tauropine was separated by reverse-phase high-performance liquid chromatography (HPLC) and detected by ultraviolet absorbance. Tauropine was detectable in the blood obtained from mice intraperitoneally injected with tauropine. However, it was not detectable in blood obtained from orally treated mice. In conclusion, oral ingested tauropine may be poorly absorbed by the gastrointestinal tract and transported into the blood.

Keywords: Bioavailability; Mass spectrometry; Tauropine.

MeSH terms

Administration, Oral
Amino Acids, Sulfur* / analysis
Animals
Biological Availability
Chromatography, High Pressure Liquid / methods
Eating
Gastropoda*
Mice

Substances

Amino Acids, Sulfur
tauropine