Facile synthesis of surface functionalized Pd2+@P-CDP/COFs for highly sensitive detection of norfloxacin drug based on the host-guest interaction

Abstract

In this work, β-cyclodextrin porous polymers (P-CDPs) functionalized novel covalent organic frameworks (P-CDPs/COFs) were synthesized by a simple and facile method. After combined with Pd²⁺ via electrostatic interaction, the Pd²⁺@P-CDPs/COFs nanocomposites were prepared and utilized as novel electrode materials to fabricate the non-enzyme electrochemical sensors for high-sensitivity detection of Norfloxacin (NF). Due to the host-guest recognition, excellent adsorption performance and catalytic performance of Pd²⁺@P-CDPs/COFs, the prepared sensor exhibited excellent electrochemical performance for detecting NF under the optimum conditions, which showed two linear ranges of 0.08-7.0 μM and 7.0-100.0 μM with a low detection limit of 0.031 μM (S/N = 3). Additionally, the obtained sensor has also been successfully applied to measure NF with satisfactory results in the real medicinal samples of NF eye-drops. Our findings paved the way for the development of COFs-based sensing platform in drug analysis and testing for human health, food security and the quality control of drugs.

Keywords: Covalent organic frameworks; Electrochemical sensor; Norfloxacin; β-cyclodextrin porous polymers.